Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke

Lenahan, Cameron; Huang, Lei; Travis, Zachary D.; Zhang, Junyi

doi:10.1186/s41016-019-0178-3

Cited by 13 publications

(4 citation statements)

References 124 publications

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“…42 On a larger scale HDL-miRNAs may have an important role in RA. Critical cells for RA pathogenesis such as macrophages, B cells, T cells, RA synovial fibroblasts and others express scavenger receptor class B type 1, [43][44][45][46] which may be required for HDL-miRNA delivery. 13 Thus, more studies are needed to determine the effect of HDL-miRNA delivery on other key cells in RA and the potential for HDL-miRNA targeting for RA treatment.…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effect of High‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

Wu,

Sheng,

Michell

et al. 2024

Arthritis & Rheumatology

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ObjectiveHigh‐density lipoprotein (HDL) has well‐characterized anti‐atherogenic cholesterol efflux and antioxidant functions. Another function of HDL uncharacterized in RA is its ability to transport microRNAs (miRNAs) between cells and thus alter cellular function. The study's purpose was to determine if HDL‐miRNA cargo is altered and affects inflammation in RA.MethodsHDL‐miRNAs were characterized in 30 RA and 30 control subjects by next generation sequencing and quantitative PCR. The most abundant differentially expressed miRNA was evaluated further. The function of miR‐1246 was assessed by miRNA mimics, antagomiRs, siRNA knockdown and luciferase assays. Monocyte‐derived macrophages were treated with miR‐1246‐loaded HDL, and unmodified HDL from RA and control subjects to measure delivery of miR‐1246 and its effect on IL‐6.ResultsThe most abundant miRNA on HDL was miR‐1246; it was significantly enriched 2‐fold on HDL from RA versus control subjects. HDL‐mediated miR‐1246 delivery to macrophages significantly increased IL6 expression 43‐fold. miR‐1246 delivery significantly decreased DUSP3 1.5‐fold and DUSP3 siRNA knockdown increased macrophage IL6 expression. Luciferase assay indicated DUSP3 is a direct target of miR‐1246. Unmodified HDL from RA delivered 1.6‐fold more miR‐1246 versus control subject HDL. Unmodified HDL from both RA and control subjects attenuated activated macrophage IL6 expression, but this effect was significantly blunted in RA so that IL6 expression was 3.4‐fold higher after RA versus control HDL treatment.ConclusionsHDL‐miR‐1246 was increased in RA versus control subjects and delivery of miR‐1246 to macrophages increased IL‐6 expression by targeting DUSP3. The altered HDL‐miRNA cargo in RA blunted HDL's anti‐inflammatory effect.image

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Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effect of High‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

Wu,

Sheng,

Michell

et al. 2024

Arthritis & Rheumatology

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“…Class B scavenger receptors includes the following members: SR-B1, SR-B2 and SR-B3. Structurally Class B scavenger receptors are constructed out of two transmembrane domains flanking an extracellular loop, with both the N-and C-termini located within the cytoplasm (80). Class B scavenger receptors mediate transport of cholesterol and lipids, and are involved in tumor development (34,35,81).…”

Section: B Scavenger Receptorsmentioning

confidence: 99%

Macrophage scavenger receptors: Tumor support and tumor inhibition

et al. 2023

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Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a large superfamily of multifunctional receptors that recognize, internalize and transport to the endosomal/lysosomal pathway apoptotic cells, cytokines, matrix molecules, lipid modified lipoproteins and other unwanted-self ligands. In our review, we summarized state-of-the art for the role of macrophage scavenger receptors in tumor development and their significance as cancer biomarkers. In this review we focused on functional activity of TAM-expressing SRs in animal models and in patients, and summarized the data for different human cancer types about the prognostic significance of TAM-expressed SRs. We discussed the role of SRs in the regulation of cancer cell biology, cell-cell and cell-matrix interaction in TME, immune status in TME, angiogenesis, and intratumoral metabolism. Targeting of tumor-promoting SRs can be a promising therapeutic approach in anti-cancer therapy. In our review we provide evidence for both tumor supporting and tumor inhibiting functions of scavenger receptors expressed on TAMs. We focused on the key differences in the prognostic and functional roles of SRs that are specific for cancer types. We highlighted perspectives for inhibition of tumor-promoting SRs in anti-cancer therapy.

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“…High-density lipoproteins (HDLs) are the smallest lipoproteins and natural carriers of RNA in vivo, ferrying and delivering miRNA to cells. , Scavenger receptor type B-1 (SR-B1) is a high-affinity receptor for spherical HDLs that exhibit surface expression of apolipoprotein A-I (apoA-I), and it is expressed in a wide variety of cell and tissue types. ,− Thus, HDLs deliver miRNA with high selectivity to cells expressing SR-B1, motivating the synthesis and evaluation of HDL-mimicking particles for RNA delivery. McMahon et al pursued this concept by developing templated lipoprotein particles (TLPs) to mimic spherical HDLs .…”

Section: Bioinspired Lipid-based Nanocarriersmentioning

confidence: 99%

Bioinspired Lipid Nanocarriers for RNA Delivery

Golubovic

Tsai

2023

ACS Bio Med Chem Au

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RNA therapy is a disruptive technology comprising a rapidly expanding category of drugs. Further translation of RNA therapies to the clinic will improve the treatment of many diseases and help enable personalized medicine. However, in vivo delivery of RNA remains challenging due to the lack of appropriate delivery tools. Current state-of-the-art carriers such as ionizable lipid nanoparticles still face significant challenges, including frequent localization to clearance-associated organs and limited (1–2%) endosomal escape. Thus, delivery vehicles must be improved to further unlock the full potential of RNA therapeutics. An emerging strategy is to modify existing or new lipid nanocarriers by incorporating bioinspired design principles. This method generally aims to improve tissue targeting, cellular uptake, and endosomal escape, addressing some of the critical issues facing the field. In this review, we introduce the different strategies for creating bioinspired lipid-based RNA carriers and discuss the potential implications of each strategy based on reported findings. These strategies include incorporating naturally derived lipids into existing nanocarriers and mimicking bioderived molecules, viruses, and exosomes. We evaluate each strategy based on the critical factors required for delivery vehicles to succeed. Finally, we point to areas of research that should be furthered to enable the more successful rational design of lipid nanocarriers for RNA delivery.

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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke

Cited by 13 publications

References 124 publications

Anti‐Inflammatory Effect of High‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

Anti‐Inflammatory Effect of High‐Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis

Macrophage scavenger receptors: Tumor support and tumor inhibition

Bioinspired Lipid Nanocarriers for RNA Delivery

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