Scavenger Receptor CD36 Mediates Inhibition of Cholesterol Synthesis via Activation of the LKB1-AMPK Pathway and Insig1/Insig2 Expression in Hepatocytes

Rodrigue-Way, Amélie; Keil, Sarah; Caron, Véronique; Bilodeau, Stéphanie; Lévy, Émile; Mitchell, Grant A.; Tremblay, André

doi:10.1016/j.jcjd.2013.08.196

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“…AMPK was first described because of its role in lipid metabolism and regulating cholesterol and fatty acid levels [ 20 , 21 ]. Since then the role of AMPK in regulating cellular energy homeostasis places this enzyme as a major regulator of energy metabolism.…”

Section: Introductionmentioning

confidence: 99%

Targeting AMPK for cancer prevention and treatment

et al. 2015

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AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and target for cancer prevention and treatment. Recent epidemiological studies indicate that treatment with metformin, an AMPK activator reduces the incidence of cancer. In this article we review the role of AMPK in regulating inflammation, metabolism, and other regulatory processes with an emphasis on cancer, as well as, discuss the potential for targeting AMPK to treat various types of cancer. Activation of AMPK has been found to oppose tumor progression in several cancer types and offers a promising cancer therapy. This review evaluates the evidence linking AMPK with tumor suppressor function and analyzes the molecular mechanisms involved. AMPK activity opposes tumor development and progression in part by regulating inflammation and metabolism.

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Section: Introductionmentioning

confidence: 99%