Scavenger and antioxidant properties of ten synthetic flavones

Cotelle, Nicole; Bernier, Jacques; Hénichart, Jean‐Pierre; Catteau, Jean‐Pierre; Gaydou, Émile M.; Wallet, Jean‐Claude

doi:10.1016/0891-5849(92)90017-b

Cited by 186 publications

(115 citation statements)

References 19 publications

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“…But they can give rise to toxic hydroxyl radicals, damaging cellular macromolecules directly or indirectly with severe consequences. [43] The superoxide radicals have been proved to play crucial roles in ischemia-reperfusion injury. [44] Thus, scavenging of these radicals would be a promising remedy for this disease.…”

Section: Superoxide Radicals Scavenging (Srs) Activitymentioning

confidence: 99%

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Pal¹,

Naika²,

Khanum³

et al. 2011

Pharmacognosy Journal

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a b s t r a c tWithania somnifera Dunal, commonly known as ashwagandha, has been used for centuries in ayurvedic medicine to increase longevity and vitality. Various groups of researchers support its polypharmaceutical uses by confirming anti-inflammatory, immuno-modulatory and antistress properties in the whole plant extract. The present investigation adds up the antioxidant assay profiling in this list. The Ashwagandha root extracts were prepared in different solvents of varied polarity in a sequential fashion. The maximum yield (5.8%) and total polyphenolic compounds (TPC, 88.58 µg GAE/mg extract) were recorded in methanolic fraction. All the extracts were screened for their potential antioxidant activities using tests such as free radical scavenging activity, metal chelation activity, hydroxyl radical scavenging activity, superoxide radical scavenging activity and hydrogen peroxide scavenging activity. Results of study showed methanolic extract as the most potent fraction and a strong correlation could be established with its TPC. Overall, the study suggests that Ashwagandha root extract could be of great use for the preparation of antioxidant rich nutraceuticles to treat various human diseases and its complications. It is quite likely that the antioxidant capacity of plant/root is one of the reasons for its established anti-stress, anti-inflammatory and immunomodulatory properties.

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Section: Superoxide Radicals Scavenging (Srs) Activitymentioning

confidence: 99%

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Pal¹,

Naika²,

Khanum³

et al. 2011

Pharmacognosy Journal

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“…Flavonoids have been deeply studied and have shown to possess innumerous biological activities from which the antioxidant properties are the best-described. [22][23][24][25][26][27] Considering the structural similarities, some of these properties are likely to be shared with 2-styrylchromones, although it needs to be experimentally confirmed. Thus, the present work consisted in studying the scavenging activities for the above-referred ROS and RNS of various 2-styrylchromone derivatives (Fig.…”

Section: Introductionmentioning

confidence: 99%

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Gomes

Fernandes

Silva

et al. 2007

Bioorganic & Medicinal Chemistry

126

173

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Abstract-2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases, IC 50 s under 1 lM. The hydroxylation pattern of 2-styrylchromones, especially in the B-ring but also in the A ring, modulates the activity of these compounds, the catecholic derivatives being the most effective scavengers. The styryl pattern also contributes to their observed outstanding antioxidant activity. In conclusion, the scavenging activities for ROS/RNS of 2-styrylchromone derivatives, here shown for the first time, provide novel and most promising compounds to be applied as antioxidants.

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“…The interest in these compounds is based on their biochemical activities, such as phosphotyrosine kinase inhibition (Akiyama et al, 1987;Glossmann et al, 1981), topoisomerase II inhibition (Markovits et al, 1989), and scavenging of free radicals (Bors et al, 1987;Cotelle et al, 1992). Recently, the synthetic compound flavopiridol has drawn considerable attention for its antiproliferative capacities as an inhibitor of cyclin-dependent kinases cdk1, cdk2, cdk4 and cdk7 (Sedlacek et al, 1996).…”

mentioning

confidence: 99%

Potent interaction of flavopiridol with MRP1

et al. 1999

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The multidrug resistance protein 1 (MRP1) is an ATP-dependent transport protein for organic anions, as well as neutral or positively charged anticancer agents. In this study we show that flavopiridol, a synthetic flavonoid currently studied in phase 1 trials for its anti-proliferative characteristics, interacts with MRP1 in a potent way. Flavopiridol, as well as other (iso)flavonoids stimulate the ATPase activity of MRP1 in a dose-dependent way at low micromolar concentrations. A new specific monoclonal antibody against MRP1 (MIB6) inhibits the (iso)flavonoid-induced ATPase activity of plasma membrane vesicles prepared from the MRP1 overexpressing cell line GLC 4 /ADR. The accumulation of daunorubicin in GLC 4 /ADR cells is increased by flavopiridol and by other non-glycosylated (iso)flavonoids that interact with MRP1 ATPase activity. However, flavopiridol is the only tested compound that affects the daunorubicin accumulation when present at concentrations below 1 μ M . Glycosylated (iso)flavonoids do not affect MRP1-mediated transport or ATPase activity. Finally, MRP1 overexpressing and transfected cells are resistant to flavopiridol, but not to other (iso)flavonoids tested. These findings may be of relevance for the development of anticancer therapies with flavopiridol. © 1999 Cancer Research Campaign

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Scavenger and antioxidant properties of ten synthetic flavones

Cited by 186 publications

References 19 publications

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

2-Styrylchromones: Novel strong scavengers of reactive oxygen and nitrogen species

Potent interaction of flavopiridol with MRP1

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