We provide a global density-dependent 4He-nucleon (DD-αN) interaction to construct the α-nucleus optical model potential (OMP) in a wide range of incident energies. The global parametrization for the DD-αN interaction is obtained based on the proton-4He OMP which reproduces the elastic scattering cross-section data very well in the incident energies of 12.04–500 MeV per nucleon. We derive the α-nucleus potential by a folding procedure with the point-nucleon density obtained by a microscopic mean-field model using the present DD-αN interaction. The density dependence of the DD-αN interaction is fixed phenomenologically to reproduce the α-nucleus elastic scattering cross-section data by the 16O, 40Ca, 58Ni, 90Zr, and 208Pb targets at E/ A = 10–342.5 MeV. We also show the total reaction cross sections, which are helpful in fixing one free parameter, the renormalization factor for the imaginary part of the α-nucleus potential. Lastly, we show some examples, which clearly demonstrate the validity and power of the present DD-αN approach.