Scatter free imaging for the improvement of breast cancer detection in mammography

Green, F H; Veale, Matthew C.; Wilson, Matthew D.; Seller, P.; Scuffham, James; Pani, S.

doi:10.1088/0031-9155/61/20/7246

Cited by 9 publications

(3 citation statements)

References 34 publications

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“…An advantage of HOPG material is that it can easily be bent to any shape since its crystallite structure releases stress on the material, as opposed to ideal crystals. Moreover, being increasingly used for monochromatization purposes 32 , it is known to additionally augment the intensity in the image plane due to the parafocusing effect 33 .…”

Section: Hopg Analyzer Crystalmentioning

confidence: 99%

Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Rosentreter

Müller

Schlattl

et al. 2017

Medical Imaging 2017: Physics of Medical Imaging

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Imaging x-ray fluorescence generally generates a conflict between the best image quality or highest sensitivity and lowest possible radiation dose. Consequently many experimental studies investigating the feasibility of this molecular imaging method, deal with either monochromatic x-ray sources that are not practical in clinical environment or accept high x-ray doses in order to maintain the advantage of high sensitivity and producing high quality images. In this work we present a x-ray fluorescence imaging setup using a HOPG crystal fan construction consisting of a Bragg reflecting analyzer array together with a scatter reducing radial collimator. This method allows for the use of polychromatic x-ray tubes that are in general easily accessible in contrast to monochromatic x-ray sources such as synchrotron facilities. Moreover this energy-selecting device minimizes the amount of Compton scattered photons while simultaneously increasing the fluorescence signal yield, thus significantly reducing the signal to noise ratio. The aim is to show the feasibility of this approach by measuring the Bragg reflected K α fluorescence signal of an object containing an iodine solution using a large area detector with moderate energy resolution. Contemplating the anisotropic energy distribution of background scattered x-rays we compare the detection sensitivity, applying two different detector angular configurations. Our results show that even for large area detectors with limited energy resolution, iodine concentrations of 0.12 % can be detected. However, the potentially large scan times and therefore high radiation dose need to be decreased in further investigations.

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Section: Hopg Analyzer Crystalmentioning

confidence: 99%

Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Rosentreter

Müller

Schlattl

et al. 2017

Medical Imaging 2017: Physics of Medical Imaging

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show abstract

“…Green et al [14] obtained scatter-free mammographic images using HEXITEC pixelated spectroscopic detector and reported an improvement of contrast up to 50%. Medipix detectors are another example of photon-counting detectors that showed potential in a wide range of applications [15].…”

Section: Introductionmentioning

confidence: 99%

Utilization of an energy-resolving detection system for mammography applications: A preliminary study

et al. 2022

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Breast cancer remains one of the major causes of mortality among female cancer patients. This fact caused a spark in the medical field, which in turn helped to improve the diagnostic and treatment of breast cancer patients over the years making this field always active with new ideas and innovative methods. In our study, a new method was explored using an energy-resolving detection system made from a NaI (Tl) scintillation detector to detect the gamma photons from an Am-241 radiation source to try and construct an image by scanning the American College of Radiology (ACR) mammography phantom. In addition to the experimental work, a Geant4 Application for Tomographic Emission (GATE) toolkit was used to investigate more complex options to improve the image quality of mammographic systems, which is limited by the experimental setup. From the experimental setup, the researchers were able to construct an image using the 26.3 keV and the 59.5 keV energy photons, to show the largest size tumour (12 mm) in the ACR phantom. With an improved setup in the simulation environment, the majority of the ACR phantom tumours was visible using both energy windows from the 26.3 keV and the 59.5 keV, where the 26.3 keV yielded better quality images showing four tumours compared to three when using 59.5 keV. The simulation results were promising; however, several improvements need to be incorporated into the experimental work so that the system can generate high-resolution mammographic images similar to the ones obtained by the GATE simulation setup.

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“…Estimation of scattered radiation can lead to scatter signal reduction strategies in clinical environment; however, it can also help in the design of image simulation frameworks by enabling the addition of the correct amount of scattered radiation in simulated image data . Some of these frameworks are used within virtual clinical trials (VCTs) for lesion detection performance .…”

Section: Introductionmentioning

confidence: 99%

Simple method for computing scattered radiation in breast tomosynthesis

et al. 2019

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Purpose: Virtual clinical trials (VCT) are a powerful imaging tool that can be used to investigate digital breast tomosynthesis (DBT) technology. In this work, a fast and simple method is proposed to estimate the two-dimensional distribution of scattered radiation which is needed when simulating DBT geometries in VCTs. Methods: Monte Carlo simulations are used to precalculate scatter-to-primary ratio (SPR) for a range of low-resolution homogeneous phantoms. The resulting values can be used to estimate the two-dimensional (2D) distribution of scattered radiation arising from inhomogeneous anthropomorphic phantoms used in VCTs. The method has been validated by comparing the values of the scatter thus obtained against the results of direct Monte Carlo simulation for three different types of inhomogeneous anthropomorphic phantoms. Results: Differences between the proposed scatter field estimation method and the ground truth data for the OPTIMAM phantom had an average modulus and standard deviation of over the projected breast area of 2.4 AE 0.9% (minimum À17.0%, maximum 27.7%). The corresponding values for the University of Pennsylvania and Duke University breast phantoms were 1.8 AE 0.1% (minimum À8.7%, maximum 8.0%) and 5.1 AE 0.1% (minimum À16.2%, maximum 7.4%), respectively. Conclusions: The proposed method, which has been validated using three of the most common breast models, is a useful tool for accurately estimating scattered radiation in VCT schemes used to study current designs of DBT system.

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Scatter free imaging for the improvement of breast cancer detection in mammography

Cited by 9 publications

References 34 publications

Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging

Utilization of an energy-resolving detection system for mammography applications: A preliminary study

Simple method for computing scattered radiation in breast tomosynthesis

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