Scar tissue to lung cancer; pathways and treatment

Sapalidis, Konstantinos; Sardeli, Chrysanthi; Pavlidis, Efstathios T; Koimtzis, Georgios; Koulouris, Charilaos; Michalopoulos, Nikolaos; Mantalovas, Stylianos; Tsiouda, Theodora; Passos, Ioannis; Kosmidis, Christoforos; Giannakidis, Dimitrios; Șurlin, Valeriu; Katsaounis, Athanasios; Alexandrou, Vyron; Amaniti, Aikaterini; Huang, Haidong; Li, Qiang; Mogoantă, Stelian Ştefăniţă; Kesisoglou, Isaac

doi:10.7150/jca.30300

Cited by 3 publications

(4 citation statements)

References 85 publications

(105 reference statements)

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“…In turn the 90° PCI image shows a high content of collagens across the entire region of fibrosis ( Figure 2 E,H,I). The localization of the collagens in the three IR images agree with the physiology of fibrotic scarring in that these proteins are produced by fibroblasts leading to accumulation of ECM components due to inflammation typically observed before invasion of cancer cells [ 21 ].The evidence for the structural and spatial distribution of collagen fibers are changes in the regions of amide I and III bands observed in mean IR spectra of the red classes. Cluster analysis of conventional and PCI IR images show that atelectasis is spectrally characterised by three classes (blue, aqua, and orange) where the spectra mainly differ by intensities of numerous bands in the region of amide I and II bands.…”

Section: Resultsmentioning

confidence: 60%

Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer

Chrabąszcz

Kamińska

Song

et al. 2021

Cancers

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The current understanding of mechanisms underlying the formation of metastatic tumors has required multi-parametric methods. The tissue micro-environment in secondary organs is not easily evaluated due to complex interpretation with existing tools. Here, we demonstrate the detection of structural modifications in proteins using emerging Fourier Transform Infrared (FTIR) imaging combined with light polarization. We investigated lungs affected by breast cancer metastasis in the orthotopic murine model from the pre-metastatic phase, through early micro-metastasis, up to an advanced phase, in which solid tumors are developed in lung parenchyma. The two IR-light polarization techniques revealed, for the first time, the orientational ordering of proteins upon the progression of pulmonary metastasis of breast cancer. Their distribution was complemented by detailed histological examination. Polarized contrast imaging recognised tissue structures of lungs and showed deformations in protein scaffolds induced by inflammatory infiltration, fibrosis, and tumor growth. This effect was recognised by not only changes in absorbance of the spectral bands but also by the band shifts and the appearance of new signals. Therefore, we proposed this approach as a useful tool for evaluation of progressive and irreversible molecular changes that occur sequentially in the metastatic process.

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Section: Resultsmentioning

confidence: 60%

Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer

Chrabąszcz

Kamińska

Song

et al. 2021

Cancers

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“…Tuberculous fibrosis may enhance the tumorigenic potential of lung cells through the NOX4-autophagy axis was documented in mouse model recently (43). Inflammatory monocytes (IMs) (referred as to phenotype "CCR2 high CD14 + CD16 low " in humans) are found in LC and play a crucial role in tumor-promoting and scar tissue formation (44)(45)(46). Lung squamous cell carcinomas (SCC) is a major subtype of LC, characterized by low survival rate and dense recruitment of the IMs, which is adequate for the distant metastasis of SCC (46).…”

Section: Mechanisms Of Chronic Inflammation Elicited By Mtb Infection In Tumorigenesismentioning

confidence: 99%

“…Inflammatory monocytes (IMs) (referred as to phenotype "CCR2 high CD14 + CD16 low " in humans) are found in LC and play a crucial role in tumor-promoting and scar tissue formation (44)(45)(46). Lung squamous cell carcinomas (SCC) is a major subtype of LC, characterized by low survival rate and dense recruitment of the IMs, which is adequate for the distant metastasis of SCC (46). Tumors recruit IMs through secretion of monocyte chemotactic protein-1 (CCL-2) (46).…”

Section: Mechanisms Of Chronic Inflammation Elicited By Mtb Infection In Tumorigenesismentioning

confidence: 99%

“…Lung squamous cell carcinomas (SCC) is a major subtype of LC, characterized by low survival rate and dense recruitment of the IMs, which is adequate for the distant metastasis of SCC (46). Tumors recruit IMs through secretion of monocyte chemotactic protein-1 (CCL-2) (46). Increased CCL-2 is also found in PTB patients (47).…”

Section: Mechanisms Of Chronic Inflammation Elicited By Mtb Infection In Tumorigenesismentioning

confidence: 99%

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Advances in molecular mechanisms of interaction between Mycobacterium tuberculosis and lung cancer: a narrative review

Xiong¹,

Sun²,

He³

et al. 2021

Transl Lung Cancer Res

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Objective: We systematically review the molecular mechanism of the interaction between lung cancer (LC) and tuberculosis (TB), and put forward the existing problems in order to provide suggestions for early intervention and future research direction.Background: TB and LC are two global public health problems affecting human health. LC is the main cause of cancer-related death worldwide and TB is one of the leading causes of death among infectious diseases, especially in resource-poor areas. Previous studies have suggested that a history of TB may be associated with an increased risk of LC. With the improvement of LC treatment, the occurrence of pulmonary tuberculosis in the course of LC treatment is also frequently reported recently. Methods:The molecular immunological mechanisms of interaction between LC and TB, and related epidemiological literature are reviewed. The research progress and problems to be solved are summarized.Conclusions: Chronic inflammation, immune abnormalities, scar formation, gene mutations and drug effects caused by TB may be associated with the occurrence of LC induced by abnormalities in various molecular pathways. LC and decreased immunity during treatment may also increase the risk of latent TB activation or new TB infection through immune pathways. Data on dual burden areas of TB and LC are still lacking, and more clinical studies are needed to elucidate the association.

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Morphological Assessment of the Lungs in Post-Covid-19 Syndrome: Analysis of Autopsy Material

Myroshnychenko

Pasiyeshvili²,

Kapustnyk³

et al. 2023

Wiad Lek

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The aim was to reveal the morphological features of the lungs in post-COVID-19 syndrome. Materials and methods: The material of the study was autopsy material – fragments of the lung tissue from 96 deceased (59 men and 37 women). During the lifetime, all patients had in anamnesis COVID-19 of varying severity, and after the treatment of this infection, they had various manifestations of respiratory failure until death. The average duration of the post-COVID-19 period was 148.6±9.5 days. Based on the severity of COVID-19 in anamnesis, all cases were divided into three groups. Group 1 included 39 cases with mild COVID-19 in anamnesis. Group 2 included 24 cases with moderate severity of COVID-19 in an¬amnesis. Group 3 included 33 cases with severe COVID-19 in anamnesis. Histological, histochemical, morphometric and statistical research methods were used. Results: Morphological features of the lungs in post-COVID-19 syndrome were the presence of pneumosclerosis; focal-diffuse immune cells infiltration; emphysematous and atelectatic changes; degenerative-desquamatic changes in the alveolar epithelium; metaplastic changes of connective tissue; dystrophic calcification; dystrophic, metaplastic and dysplastic changes in the epithelial layer of bronchial tree; hemodynamic disorders. Pneumosclerosis, focal-diffuse immune cells infiltration, alterative changes in the alveolar epithelium, emphysematous and atelectatic changes, hemodynamic disorders increased with an increase the severity of COVID-19. Metaplastic changes of connective tissue, dystrophic calcification, dystrophic, metaplastic and dysplastic changes in epithelial layer of bronchial tree did not depend on the severity of the infection. Conclusions: The changes identified by the authors help to explain pulmonary manifestations of post-COVID-19 syndrome. They should be the basis for the oncological alertness formation among doctors, the development of rehabilitation and treatment measures for such category of patients.

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Scar tissue to lung cancer; pathways and treatment

Cited by 3 publications

References 85 publications

Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer

Fourier Transform Infrared Polarization Contrast Imaging Recognizes Proteins Degradation in Lungs upon Metastasis from Breast Cancer

Advances in molecular mechanisms of interaction between Mycobacterium tuberculosis and lung cancer: a narrative review

Morphological Assessment of the Lungs in Post-Covid-19 Syndrome: Analysis of Autopsy Material

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