Scar Symptom: Erythema and Thickness

Abstract

Erythema is a word derived from the Greek erythros, which describes red color of the skin or mucous membrane. In particular, erythema and redness in scar are important as they are closely related to scar symptoms and tissue maturation, and thus can serve as an indicator for scar prognosis. There is rich information in the literature regarding its clinical manifestation, pathological mechanism, and its relation to inflammation and symptoms of pain and itching as well as the clinical treatment. Scar thickness reflects the accumulation of collagen content and there is no necessary association between scar redness and thickness. This chapter mainly focuses on the overview of scar erythema/redness in the aspects of definition, possible mechanism related to clinical manifestation and symptoms, and finally the therapeutic options.

Tailored versus conventional surgical debridement in complex facial lacerations: a retrospective study

“…Extended scar spread is the result of a rupture of the dermis and excessive tension. Erythema results from increased local blood ow and vascular permeability of capillaries stimulated by the in ammatory cytokines [26,27]. Dyspigmentation may result from in ammatory conditions, and a hypertrophic scar results from excessive proliferation of myo broblasts and increased collagen deposition within the scar [26,28].…”

“…Dyspigmentation may result from in ammatory conditions, and a hypertrophic scar results from excessive proliferation of myo broblasts and increased collagen deposition within the scar [26,28]. As an adjunct to collagen production, the synthesis of histamine is increased, and the response of histamine receptors is activated, resulting in pruritus [27]. Furthermore, various substances such as acetylcholine, bradykinin, and proteinases are involved in pruritic sensations [29].…”

Tailored versus conventional surgical debridement in complex facial lacerations in emergency department: a retrospective study

“…Erythema results from increased local blood ow and vascular permeability of capillaries stimulated by the in ammatory cytokines 26,27 . Dyspigmentation may result from in ammatory conditions, and a hypertrophic scar results from excessive proliferation of myo broblasts and increased collagen deposition within the scar 26,28 .…”

Tailored versus conventional surgical debridement in complex facial lacerations in emergency department: A retrospective study

“…Erythema results from increased local blood flow and vascular permeability of capillaries stimulated by inflammatory cytokines. [26,27] Dyspigmentation may result from inflammatory conditions, and hypertrophic scars result from the excessive proliferation of myofibroblasts and increased collagen deposition within the scar. [26,28] As an adjunct to collagen production, the synthesis of histamine is increased, and the response of histamine receptors is activated, resulting in pruritus.…”

“…[26,28] As an adjunct to collagen production, the synthesis of histamine is increased, and the response of histamine receptors is activated, resulting in pruritus. [27] Furthermore, various substances such as acetylcholine, bradykinin, and proteinases are involved in pruritic sensations. [29] This also means that, compared to CSD, TSD can lower the inflammatory response in the wound healing process and approximate the wound edge by making it a relatively intact edge.…”