Scar-Related Ventricular Tachycardia: Pathophysiology, Diagnosis, and Management

Abstract

Scar-related ventricular tachycardia (VT) commonly results from scarring in the myocardium, principally produced by antecedent myocardial infarction, cardiomyopathy, or prior cardiac surgery. The resultant arrhythmogenic substrate from scarred tissue and the alteration of normal cardiac electrical conduction predispose patients to reentrant circuits, followed by VT. This literature review synthesizes current research on pathophysiology, diagnostic methods, and treatment modalities of scar-related VT. The primary contents of the review are descriptions of the mechanisms through which myocardial fibrosis results in VT, clinical presentations of the condition, and advanced diagnostic techniques, including electrophysiological studies and mapping. Furthermore, the review outlines the various management strategies, such as implantable cardioverter-defibrillators, catheter ablation, stereotactic arrhythmia radioablation, and surgical ablation. The discussion also includes emerging therapeutics, such as gene therapy, artificial intelligence, and precision medicine in managing scar-related VT, emphasizing the ongoing advancements aimed at improving patient outcomes.