Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears

Jun-Zeng,; Huang, Tian-Yu; Wang, Zhenzhen; Gong, Yongfang; Liu, Xing-Cun; Zhang, Xiaoming; Huang, Xueying

doi:10.1016/j.intimp.2020.107200

Cited by 12 publications

(6 citation statements)

References 31 publications

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“…The masking noise in AMTAS could have contributed to the central masking effect which has been shown to affect the 2 kHz AC threshold more thereby resulting in a greater difference for the 2 kHz threshold obtained via the two methods. 20 The larger absolute difference at 2 kHz observed in this study as compared to the study by Eikelbloom's group may be due to the different headphones used for manual PTA in the two studies. In this study, circum-aural headphones were used whereas in the study by Eikelbloom's group, supra-aural headphones were used.…”

Section: Questioncontrasting

confidence: 54%

A pilot study to validate AMTAS in a specialist outpatient clinic at a public restructured hospital in Singapore

Hui

Chua

Kamath

et al. 2023

Proceedings of Singapore Healthcare

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Background The prevalence of age-related hearing loss is expected to increase with the ageing population in Singapore resulting in increased demand for pure tone audiometry (PTA). One way of meeting the increased demand for PTA is the Automated Method of Testing Auditory Sensitivity (AMTAS). Nonetheless, before AMTAS may be implemented, it is important to validate its results by comparing them against those of conventional PTA for the diverse Singaporean population. Methods 100 participants were recruited from the Otorhinolaryngology clinic at a public hospital. PTA was conducted for participants via the conventional method and AMTAS. The hearing thresholds obtained via the two methods were then compared. A feedback questionnaire on the use of AMTAS was also completed by all participants. Results Air and bone conduction threshold results from 80 participants were analysed. The absolute mean difference in air conduction thresholds obtained via the two methods ranged from 3.30 to 9.62 dB. The absolute mean difference in bone conduction thresholds obtained via the two methods ranged from 8.16 to 9.38 dB. Most participants indicated that the machine was easy to use. Other feedback collected indicated that the AMTAS testing environment was noisy and that testing was fast. Conclusion This study finds that despite differences in hearing thresholds obtained via AMTAS and manual PTA, these differences are within the acceptable 10 dB test-retest variation. Nonetheless, existing issues related to the AMTAS software and noise levels in the testing environment will need to be addressed before it can be used in the clinic.

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Section: Questioncontrasting

confidence: 54%

A pilot study to validate AMTAS in a specialist outpatient clinic at a public restructured hospital in Singapore

Hui

Chua

Kamath

et al. 2023

Proceedings of Singapore Healthcare

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“…Previously, we also found the anti‐angiogenic effect of UA (usnic acid) using the rabbit ear scarring model 41 . Huang et al revealed that gambogenic acid (GNA) hindered HS formation by inhibiting angiogenesis, inflammation, and growth factor expression 42 . In a double‐blind, randomized trial, the authors showed that topical application of EGCG exhibited a beneficial role for scar therapy via reducing VEGFA and CD31 expression 14 .…”

Section: Discussionmentioning

confidence: 95%

“…41 acid (GNA) hindered HS formation by inhibiting angiogenesis, inflammation, and growth factor expression. 42 In a double-blind, randomized trial, the authors showed that topical application of EGCG exhibited a beneficial role for scar therapy via reducing VEGFA and CD31 expression. 14 In this study, we found that EGCG dramatically reduced the number of capillaries in the scar tissues, which is conducive to inhibiting scar formation.…”

Section: Discussionmentioning

confidence: 99%

EGCG inhibits hypertrophic scar formation in a rabbit ear model

Song

Wang

Yang

et al. 2023

J of Cosmetic Dermatology

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Objective Hypertrophic scarring is a common skin fibro‐proliferative disease, but currently there has no satisfactory drugs for anti‐scar treatments. Previous study showed that epigallocatechin gallate (EGCG), the main catechin in green tea, improved wound healing and tissue fibrosis in both rats and mice. In the present study, the therapeutic effects of EGCG on hypertrophic scar were analyzed using a rabbit ear hypertrophic scar model. Materials A rabbit ear model of hypertrophic scarring was used. DMSO, 0.5 mg EGCG/wound, 1.0 mg EGCG/wound or triamcinolone were injected subcutaneously once a week for 4 weeks. The scar elevation index (SEI) was measured using HE staining images, the collagen fibers were examined by Masson’ trichrome staining images, and the number of capillaries in hypertrophic scar were calculated by CD31 staining images. The mRNA levels in the scar tissues were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Results Gross observation and histological evaluation showed the inhibitory effects of EGCG on hypertrophic scar formation at both doses, and decreased scar height and SEI were detected. EGCG also attenuated the mean collagen area fraction and decreased the number of capillaries in scar tissues. qRT‐PCR revealed that EGCG significantly inhibited the mRNA expression of TGF‐β1, Col I, Col III, α‐SMA, and eNOS. Conclusion EGCG may serve as a useful candidate therapeutic drug for hypertrophic scar via inhibiting fibrotic gene expression and suppressing angiogenesis.

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“…Fourthmore, it suppressed the formation of HS by reducing the secretion of IL-1, IL-6 and IL-8 (Jia et al, 2014), which the same as naringin (Shan et al, 2017). IL-6 level was also influenced by other natural extracts such as Ginseng (Pazyar et al, 2012), Ginsenoside Rg3 (Ma et al, 2020), Gambogenic acid (GNA) (Jun et al, 2021) and Lapadan (Matsui et al, 2011), which reduced the rates of hypertrophic scar formation.…”

Section: Natural Extraction Medicinementioning

confidence: 96%

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid

Zhang

Zhao

2021

Front. Pharmacol.

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Hypertrophic scar (HS) and keloid are fibroproliferative disorders (FPDs) of the skin due to aberrant wound healing, which cause disfigured appearance, discomfort, dysfunction, psychological stress, and patient frustration. The unclear pathogenesis behind HS and keloid is partially responsible for the clinical treatment stagnancy. However, there are now increasing evidences suggesting that inflammation is the initiator of HS and keloid formation. Interleukins are known to participate in inflammatory and immune responses, and play a critical role in wound healing and scar formation. In this review, we summarize the function of related interleukins, and focus on their potentials as the therapeutic target for the treatment of HS and keloid.

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Scar-reducing effects of gambogenic acid on skin wounds in rabbit ears

Cited by 12 publications

References 31 publications

A pilot study to validate AMTAS in a specialist outpatient clinic at a public restructured hospital in Singapore

A pilot study to validate AMTAS in a specialist outpatient clinic at a public restructured hospital in Singapore

EGCG inhibits hypertrophic scar formation in a rabbit ear model

Therapeutic Strategies by Regulating Interleukin Family to Suppress Inflammation in Hypertrophic Scar and Keloid

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