Scar‐free cutaneous wound healing in the leopard gecko, <i>Eublepharis macularius</i>

Peacock, Hanna M.; Gilbert, Emily; Vickaryous, Matthew K.

doi:10.1111/joa.12368

Cited by 30 publications

(47 citation statements)

References 55 publications

(177 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This increased thickening of the WE is consistent with previous investigations of cutaneous wound healing in lizards (Peacock et al. ; see also Wu et al. ).…”

Section: Resultssupporting

confidence: 92%

“…The pattern of wound healing and regeneration observed was consistent with previous reports (Peacock et al. ). Blood loss from the biopsy wounds was minimal, and haemostasis was naturally achieved within several minutes, no exogenous methods to control haemorrhaging were required.…”

Section: Resultssupporting

confidence: 92%

“…; see also Bellairs & Bryant, ), and cutaneous wound healing (Peacock et al. ), tubercle scales were not regenerated. Instead, the regenerated skin was clad exclusively in small (~ 2 mm) low‐profile scales, comparable to those of the original (uninjured) tissue.…”

Section: Resultsmentioning

confidence: 93%

“…The WE remained unpigmented until ~ 14 DPW (Peacock et al. ). By 45 DPW scalation and pigmentation had essentially been restored (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…; Peacock et al. ). We determined that gecko keratinocytes, like those of mammals, express a diversity of growth factor ligands and receptors under homeostatic and injury‐mediated conditions.…”

mentioning

confidence: 98%

See 4 more Smart Citations

VEGF,FGF‐2 andTGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles

2018

Self Cite

View full text Add to dashboard Cite

The skin is a bilayered organ that serves as a key barrier between an organism and its environment. In addition to protecting against microbial invasion, physical trauma and environmental damage, skin participates in maintaining homeostasis. Skin is also capable of spontaneous self-repair following injury. These functions are mediated by numerous pleiotrophic growth factors, including members of the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor β (TGFβ) families. Although growth factor expression has been well documented in mammals, particularly during wound healing, for groups such as reptiles less is known. Here, we investigate the spatio-temporal pattern of expression of multiple growth factors in normal skin and following a full-thickness cutaneous injury in the representative lizard Eublepharis macularius, the leopard gecko. Unlike mammals, leopard geckos can heal cutaneous wounds without scarring. We demonstrate that before, during and after injury, keratinocytes of the epidermis express a diverse panel of growth factor ligands and receptors, including: VEGF, VEGFR1, VEGFR2, and phosphorylated VEGFR2; FGF-2 and FGFR1; and phosphorylated SMAD2, TGFβ1, and activin βA. Unexpectedly, only the tyrosine kinase receptors VEGFR1 and FGFR1 were dynamically expressed, and only during the earliest phases of re-epithelization; otherwise all the proteins of interest were constitutively present. We propose that the ubiquitous pattern of growth factor expression by keratinocytes is associated with various roles during tissue homeostasis, including protection against ultraviolet photodamage and coordinated body-wide skin shedding.

show abstract

“…This increased thickening of the WE is consistent with previous investigations of cutaneous wound healing in lizards (Peacock et al. ; see also Wu et al. ).…”

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 93%

“…The WE remained unpigmented until ~ 14 DPW (Peacock et al. ). By 45 DPW scalation and pigmentation had essentially been restored (Fig.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 98%

See 3 more Smart Citations