Scar cancer of the lung

Ripstein, Chas. B.; Spain, David M.; Bluth, Irwin

doi:10.1016/s0022-5223(19)42827-4

Cited by 34 publications

(3 citation statements)

References 5 publications

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“…The relationship between pulmonary TB and bronchogenic carcinoma has been viewed in the following ways: (A) As one of cause and effect (scar cancer). Many researchers believe that scar tissue plays an important causative role in the development of lung cancer ( 9 , 10 ); (B) As the reactivation of TB by carcinoma. It has also been reported that the development of lung cancer in areas of inactive TB stimulates the reactivation of tubercle bacilli ( 5 , 11 ).…”

Section: Discussionmentioning

confidence: 99%

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

et al. 2001

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ObjectiveBronchogenic Carcinoma Can Mimic Or Be Masked By Pulmonary Tuberculosis (Tb), And The Aim Of This Study Was To Describe The Radiologic Findings And Clinical Significance Of Bronchogenic Carcinoma And Pulmonary Tb Which Coexist In The Same Lobe.Materials and MethodsThe findings of 51 patients (48 males and three females, aged 48-79 years) in whom pulmonary TB and bronchogenic carcinoma coexisted in the same lobe were analyzed. The morphologic characteristics of a tumor, such as its diameter and margin, the presence of calcification or cavitation, and mediastinal lymphadenopathy, as seen at CT, were retrospectively assessed, and the clinical stage of the lung cancer was also determined. Using the serial chest radiographs available for 21 patients, the possible causes of delay in the diagnosis of lung cancer were analyzed.ResultsLung cancers with coexisting pulmonary TB were located predominantly in the upper lobes (82.4%). The mean diameter of the mass was 5.3 cm, and most tumors (n=42, 82.4%) had a lobulated border. Calcification within the tumor was seen in 20 patients (39.2%), and cavitation in five (9.8%). Forty-two (82.4%) had mediastinal lymphadenopathy, and more than half the tumors (60.8%) were at an advanced stage [IIIB (n=11) or IV (n=20)]. The average delay in diagnosing lung cancer was 11.7 (range, 1-24) months, and the causes of this were failure to observe new nodules masked by coexisting stable TB lesions (n=8), misinterpretation of new lesions as aggravation of TB (n=5), misinterpretation of lung cancer as tuberculoma at initial radiography (n=4), masking of the nodule by an active TB lesion (n=3), and subtleness of the lesion (n=1).ConclusionMost cancers concurrent with TB are large, lobulated masses with mediastinal lymphadenopathy, indicating that the morphologic characteristics of lung cancer with coexisting pulmonary TB are similar to those of lung cancer without TB. The diagnosis of lung cancer is delayed mainly because of masking by a tuberculous lesion, and this suggests that in patients in whom a predominant or growing nodule is present and who show little improvement of symptoms despite antituberculous or other medical therapy, coexisting cancer should be suspected.

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Section: Discussionmentioning

confidence: 99%

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

et al. 2001

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“…The relationship between pulmonary tuberculosis and lung cancer has been reviewed. 10 - 12 In fact, the coexistence of lung cancer and pulmonary tuberculosis, even in the same lobe, is relatively common in Korea. 13 Therefore, we should not exclude the possibility of coexisting pulmonary tuberculosis during a diagnostic workup of lung cancer, and routine bronchoscopic culture may play a role in the diagnosis of unexpected pulmonary tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

The Value of Routinely Culturing for Tuberculosis During Bronchoscopies in an Intermediate Tuberculosis-Burden Country

et al. 2007

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PurposeMany medical centers routinely culture bronchoscopy samples for Mycobacterium tuberculosis, even when tuberculosis is not strongly suspected. The value of this practice, however, is controversial. We evaluated the role of that procedure in the diagnosis of pulmonary tuberculosis in an intermediate tuberculosis-burden country.Patients and MethodsA prospective, observational study was conducted in a tertiary referral center and included 733 consecutive patients who underwent bronchoscopy examination.ResultsM. tuberculosis was isolated in 47 patients (6.4%). According to radiographic features, the rate of positive culture for M. tuberculosis was relatively high in patients with atelectasis (5/33, 15.2%) and those with pulmonary infiltrations of suspicious infections (26/183, 14.2%). M. tuberculosis was isolated even in patients with pulmonary masses (9/266, 3.4%) and those with pulmonary nodules (5/175, 2.9%). In 16/47 (34.0%) patients with positive cultures for M. tuberculosis, active pulmonary tuberculosis was not suspected at the time of bronchoscopy.ConclusionThese results suggest that routinely culturing for M. tuberculosis during bronchoscopy is still useful in the diagnosis of pulmonary tuberculosis in an intermediate tuberculosis-burden country.

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“…Since the turn of the 19th century reports have appeared in the literature confirming that cancer can arise in old bum scars, chronic ulcers, sinus tracts, fistulas of various origins, and longexisting wounds where a prolonged process of repair has taken place (Giblin et al, 1965). Fibrous tumors and sarcomas arising in chronic osteomyelitis sinuses, laparotomy, or amputation scars (Ju, 1966) and cancer arising in old tuberculosis scars, healed bronchiectases, infarcts, and foreign body scars (Limas et al, 1971;Ripstein et al, 1968) have also been described.…”

Section: Introductionmentioning

confidence: 99%

Breast cancer arising in surgical scars

Freund

Biran

Laufer

et al. 1976

Journal of Surgical Oncology

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Twelve women who developed breast cancer at the site of old surgical scars in the breast are presented. Six had had former breast biopsies, 3 drainage of breast abscesses, and 3 developed breast cancer in old thoracotomy scars transversing the breast. The combination of trauma as an oncogen and scar tissue as a functional and immunological locus minoris resistentia seems to play a major role in the development of breast cancer in this group of patients. The associaton of breast cancer, scar, and trauma would not be coincidental. Increased attention drawn to this entity may lead to a rise in the number of cases diagnosed among patients with breast scars after biopsies, abscesses, trauma, or foreign body implantation.

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Scar cancer of the lung

Cited by 34 publications

References 5 publications

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

Coexisting Bronchogenic Carcinoma and Pulmonary Tuberculosis in the Same Lobe: Radiologic Findings and Clinical Significance

The Value of Routinely Culturing for Tuberculosis During Bronchoscopies in an Intermediate Tuberculosis-Burden Country

Breast cancer arising in surgical scars

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