Scanning probe microscopic imaging of guanine on a highly oriented pyrolytic graphite electrode

Chiorcea, Ana-Maria; Oliveira-Brett, Ana Maria

doi:10.1016/s1567-5394(01)00168-2

Cited by 11 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28 An anisotropic patterned assembly of single- and double-stranded DNA on graphene nanoribbons (GNRs) was ascribed to the donor–acceptor interactions, wherein electric dipole and van der Waals (vdW) coupling facilitates the charge transfer between DNA and GNRs. 34 Atomic force microscopy (AFM) imaging of G molecules on freshly cleaved HOPG 35 showed that G molecules condense in small nuclei without the formation of an ordered assembly. Likewise, molecular packing of adenine on a (0001) graphite surface was found to be commensurate with the graphite surface.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Self-Assembly of Noncanonical Guanine Nucleobases on Graphene

et al. 2017

View full text Add to dashboard Cite

Self-assembly characterizes the fundamental basis toward realizing the formation of highly ordered hierarchical heterostructures. A systematic approach toward the supramolecular self-assembly of free-standing guanine nucleobases and the role of graphene as a substrate in directing the monolayer assembly are investigated using the molecular dynamics simulation. We find that the free-standing bases in gas phase aggregate into clusters dominated by intermolecular H-bonds, whereas in solvent, substantial screening of intermolecular interactions results in π-stacked configurations. Interestingly, graphene facilitates the monolayer assembly of the bases mediated through the base–substrate π–π stacking. The bases assemble in a highly compact network in gas phase, whereas in solvent, a high degree of immobilization is attributed to the disruption of intermolecular interactions. Graphene-induced stabilization/aggregation of free-standing guanine bases appears as one of the prerequisites governing molecular ordering and assembly at the solid/liquid interface. The results demonstrate an interplay between intermolecular and π-stacking interactions, central to the molecular recognition, aggregation dynamics, and patterned growth of functional molecules on two-dimensional nanomaterials.

show abstract

Section: Introductionmentioning

confidence: 99%

Hierarchical Self-Assembly of Noncanonical Guanine Nucleobases on Graphene

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Computational studies have verified the experimental results [23] . However reports on direct application of nucleic acids or their fragments in the field of electronics and batteries are limited [24–27] . We have previously reported an Li guanine complex as an electrolyte displaying high Li‐ion transference number and conductivity [27] …”

Section: Introductionmentioning

confidence: 55%

“…[23] However reports on direct application of nucleic acids or their fragments in the field of electronics and batteries are limited. [24][25][26][27] We have previously reported an Li guanine complex as an electrolyte displaying high Li-ion transferencenumber andc onductivity. [27] Earlier reports have highlighted the significance of nucleobases in electronic conductivity owing to their p-electron overlap.…”

Section: Introductionmentioning

confidence: 99%

Environmentally Benign, Intrinsically Coordinated, Lithium‐Based Solid Electrolyte with a Modified Purine as Supporting Ligand

Avasthi

Gaganjot

Katiyar

et al. 2020

Chemistry A European J

View full text Add to dashboard Cite

Bioinspired materials have become increasingly competitive for electronic applications in recent years owing to the environment‐friendly alternatives they offer. The notion of biocompatible solid organic electrolytes addresses the issues concerning potential leakage of corrosive liquids, volatility and flammability of electrolyte solvents. This study presents a new intrinsically coordinated LiI adenine complex that exhibits electrical conductivity as a solid electrolyte capable of self‐sustained supply of LiI ions. It exhibits conductivity through moisture‐assisted LiI ion motion up to 373 K, and possibly by an ion‐hopping mechanism beyond 373 K. This purine‐derived solid electrolyte shows enhanced conductivity and transference number demonstrating the potential of purine‐based ligands and their coordination complexes in interesting materials applications.

show abstract

“…The 8-oxoG is the G base oxidation product at the C8 position, and presents several tautomeric forms in aqueous solution, the most stable being the 6,8-diketo I tautomer, with an oxo group at the C8 position and a H atom at the N7 positions, as shown in Scheme 4 [37][38][39][40]. The electrochemical oxidation mechanisms of G and guanosine at carbon electrodes, with the formation of 8-oxoG and 8-oxodG, have been extensively studied under different experimental conditions [2,4,10,11,13,[16][17][18]29,32,36,[41][42][43][44][45]. The oxidation of DNA nucleosides, deoxyadenosine (dA), deoxyguanosine (dG), deoxythymidine (dT) and deoxycytidine (dC), occurs at the same potentials as the nucleotides, GMP, AMP, thymidine monophosphate (TMP) and cytidine monophosphate (CMP), as shown in Figure 1, with dG and GMP at Ep ~ +0.95 V, dA and AMP at Ep ~ +1.21 V, dT and TMP at Ep ~ +1.41 V, and dC and CMP at Ep ~ +1.56 V (vs. Ag/AgCl, 3 M KCl), at pH = 7.4, being shifted to more positive potentials, compared with the bases' oxidation potentials [32].…”

Section: Electrochemical Detection Of 8-oxodg and 28-dha Biomarkers mentioning

confidence: 99%

DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage

Chiorcea-Paquim

Oliveira-Brett

2021

Sensors

View full text Add to dashboard Cite

Deoxyribonucleic acid (DNA) electrochemical biosensors are devices that incorporate immobilized DNA as a molecular recognition element on the electrode surface, and enable probing in situ the oxidative DNA damage. A wide range of DNA electrochemical biosensor analytical and biotechnological applications in pharmacology are foreseen, due to their ability to determine in situ and in real-time the DNA interaction mechanisms with pharmaceutical drugs, as well as with their degradation products, redox reaction products, and metabolites, and due to their capacity to achieve quantitative electroanalytical evaluation of the drugs, with high sensitivity, short time of analysis, and low cost. This review presents the design and applications of label-free DNA electrochemical biosensors that use DNA direct electrochemical oxidation to detect oxidative DNA damage. The DNA electrochemical biosensor development, from the viewpoint of electrochemical and atomic force microscopy (AFM) characterization, and the bottom-up immobilization of DNA nanostructures at the electrode surface, are described. Applications of DNA electrochemical biosensors that enable the label-free detection of DNA interactions with pharmaceutical compounds, such as acridine derivatives, alkaloids, alkylating agents, alkylphosphocholines, antibiotics, antimetabolites, kinase inhibitors, immunomodulatory agents, metal complexes, nucleoside analogs, and phenolic compounds, which can be used in drug analysis and drug discovery, and may lead to future screening systems, are reviewed.

show abstract

Scanning probe microscopic imaging of guanine on a highly oriented pyrolytic graphite electrode

Cited by 11 publications

References 4 publications

Hierarchical Self-Assembly of Noncanonical Guanine Nucleobases on Graphene

Hierarchical Self-Assembly of Noncanonical Guanine Nucleobases on Graphene

Environmentally Benign, Intrinsically Coordinated, Lithium‐Based Solid Electrolyte with a Modified Purine as Supporting Ligand

DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage

Contact Info

Product

Resources

About