Scanning laser polarimetry in patients with acute angle-closure glaucoma

Tsai, Jui‐Chang; Hw, Chang

doi:10.1038/sj.eye.6700517

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…Looking at sectorial parameters, inferior average was the only sectorial parameter that was significantly abnormal at 18 months (p<0.05). This result is partly in keeping with Tsai et al who have reported a thinning of both superior and inferior average [36]. The main difference between these studies could be attributed to differences in population and numbers of examined patients.…”

Section: Gdx Evidence Of Damagesupporting

confidence: 88%

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

Normando¹

2015

J Clin Exp Ophthalmol

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Irreversible damage to the optic nerve can follow the rapid increase of IOP during an acute primary angle closure (APAC). Despite the development of advanced imaging technology, there is still a lack of good longitudinal studies assessing patients after an acute attack. The aim of this study was to assess the progression of patients using different objective optic nerve head and retinal imaging parameters following APAC.Twenty patients with a single attack of APAC, were retrospectively assessed in this study. Patients were assessed with the Heidelberg retinal tomography (HRT3) and scanning laser polarimeter (GDx-VCC) as well as Humphrey visual field (HVF) repeatedly up to eighteen months after the acute attack. Progression for each imaging modality was assessed with multiple parameters.All patients showed retinal nerve fibre layer (RNFL) and optic disc changes over time. At 18 months, 67% of patients showed progression in 4/5 GDx parameters, and 33% in all 5. HRT analysis similarly showed progression in 4/5 parameters in 70% of patients, and 30% in all 5.This study shows that structural progressive changes to RNFL and ONH occur following APAC confirming that APAC patients need long-term follow-up after the acute attack.

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Section: Gdx Evidence Of Damagesupporting

confidence: 88%

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

Normando¹

2015

J Clin Exp Ophthalmol

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“…1,2,6,9 Our finding that peripapillary RNFL loss following APAC was associated with pale discs and visual field loss has not been previously reported. Previous studies have shown that an episode of APAC is associated with RNFL loss, detectable by both scanning laser polarimetry and OCT, [3][4][5] but the functional consequence of this is unclear. Our results also provide new data that APAC results in a decrease in outer macular volume, though this was not associated with significant visual field defects or optic disc pallor.…”

Section: Discussionmentioning

confidence: 97%

“…Many studies report a poor long-term visual outcome after APAC, with high rates of blindness and glaucomatous optic neuropathy. 1,2 Retinal nerve fibre layer (RNFL) loss, [3][4][5] optic nerve head (ONH) damage, 6,7 and visual field defects [8][9][10] have been described following APAC. However, the severity of these sequelae is not well established, and little is known about the correlation between them.…”

Section: Introductionmentioning

confidence: 99%

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

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et al. 2011

Eye

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Aims/Purpose To determine and correlate the long-term changes in retinal nerve fibre layer (RNFL) thickness, optic nerve head (ONH) morphology, and visual fields after a single episode of acute primary angle closure (APAC). Methods This was a cross-sectional comparative study of patients at National University Hospital (Singapore) from 2000 to 2006 after an episode of unilateral APAC. The peripapillary and macular RNFL were measured using Stratus optical coherence tomography (OCT) and ONH configuration was assessed using Heidelberg Retina Tomography (HRT)-III. Humphrey perimetry was also performed, and the presence of disc pallor was noted. APAC eyes were compared with fellow eyes as matched controls. Results Twenty-five patients were assessed at a median of 33 months (range, 11-85 months) after APAC. OCT showed that there was a reduction in the peripapillary and outer macular RNFL thickness in APAC eyes compared with controls. Humphrey perimetry revealed significantly reduced mean deviation (P ¼ 0.006) and increased pattern standard deviation (P ¼ 0.045) in APAC eyes compared with controls. HRT-III showed no difference in mean rim area, rim volume, or cup-disc ratio between APAC eyes and controls. Disc pallor was present in nine APAC eyes (36%) but was absent in fellow eyes (P ¼ 0.002), and was associated with peripapillary RNFL thinning, visual field loss, and an increased interval between the onset of symptoms and normalization of intraocular pressure (P ¼ 0.023). Conclusion APAC results in peripapillary and outer macular RNFL loss, visual field defects, and optic disc pallor, even in cases in which the ONH configuration remains unchanged.

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“…If left untreated, persistently high intraocular pressure (IOP) can lead to synechial angle damage and glaucomatous optic neuropathy 1 3. A long duration of raised IOP has been associated with retinal nerve fibre layer thinning,4 5 significant visual field defects6 7 and disc pallor 2. Conventional treatment of APAC involves reducing the IOP with systemic and topical medications, such as acetazolamide and β-blockers, followed by laser peripheral iridotomy to relieve the pupil block 8 9.…”

Section: Introductionmentioning

confidence: 99%

Anterior segment morphology after acute primary angle closure treatment: a randomised study comparing iridoplasty and medical therapy

et al. 2015

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Scanning laser polarimetry in patients with acute angle-closure glaucoma

Cited by 16 publications

References 26 publications

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

Objective Assessment of Progression after Acute Primary Angle Closure Using HRT and GDx

Changes in retinal nerve fibre layer, optic nerve head morphology, and visual field after acute primary angle closure

Anterior segment morphology after acute primary angle closure treatment: a randomised study comparing iridoplasty and medical therapy

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