Scanning Fiber Angioscopy

Savastano, Luis; Seibel, Eric J.

doi:10.1093/neuros/nyx322

Cited by 10 publications

(7 citation statements)

References 51 publications

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“…This work represents the application of high-resolution SF angioscopy to in vivo endovascular surgery and builds on the previous proof-of-concept works in ex vivo human and animal tissue. 13–15 These results demonstrate the potential of the technique to enable “operating” entirely from within the vessel lumen, a potentially significant evolutionary step in many endovascular interventions. Any future clinical application of scanning fiber angioscopy will, however, require quantitative data to support its utility in comparison with fluoroscopy, OCT, and IVUS, all of which continue to evolve at a rapid pace.…”

Section: Discussionmentioning

confidence: 81%

“…12 SF angioscopy has recently been shown to be useful in an animal model of neurovascular thrombectomy 13 and in the ex vivo inspection of human atherosclerotic lesions. 14,15 This work demonstrates the feasibility and utility of using the SF angioscope in addition to fluoroscopy for guidance of common endovascular interventions in a porcine model. The purpose of the study was to refine the angioscopic technique while developing potential clinical applications.…”

Section: Introductionmentioning

confidence: 85%

“…12 SF angioscopy has recently been shown to be useful in an animal model of neurovascular thrombectomy 13 and in the ex vivo inspection of human atherosclerotic lesions. 14,15…”

Section: Introductionmentioning

confidence: 99%

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High-Resolution Scanning Fiber Angioscopy as an Adjuvant to Fluoroscopy During Endovascular Interventions

et al. 2018

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 85%

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High-Resolution Scanning Fiber Angioscopy as an Adjuvant to Fluoroscopy During Endovascular Interventions

et al. 2018

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“…Angioscopy has also been used for the prediction of ACS events, thrombus formation, and analyses of plaques following the deployment of drug-eluting stents ( 64 ). Savastano et al ( 65 ) developed a high-resolution multimodal scanning fiber angioscopy (SFA) approach enabling the direct visualization of the intraluminal vascular surface to detect subtle thrombotic ulcers or other lesions in non-stenotic atherosclerotic plaques or the context of low-grade arterial stenosis. Coronary angiography is also a highly specific approach to intravascular thrombus detection.…”

Section: Non-molecular Imaging Of Thrombosismentioning

confidence: 99%

Molecular Imaging and Non-molecular Imaging of Atherosclerotic Plaque Thrombosis

Guo

et al. 2021

Front. Cardiovasc. Med.

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Thrombosis in the context of atherosclerosis typically results in life-threatening consequences, including acute coronary events and ischemic stroke. As such, early detection and treatment of thrombosis in atherosclerosis patients is essential. Clinical diagnosis of thrombosis in these patients is typically based upon a combination of imaging approaches. However, conventional imaging modalities primarily focus on assessing the anatomical structure and physiological function, severely constraining their ability to detect early thrombus formation or the processes underlying such pathology. Recently, however, novel molecular and non-molecular imaging strategies have been developed to assess thrombus composition and activity at the molecular and cellular levels more accurately. These approaches have been successfully used to markedly reduce rates of atherothrombotic events in patients suffering from acute coronary syndrome (ACS) by facilitating simultaneous diagnosis and personalized treatment of thrombosis. Moreover, these modalities allow monitoring of plaque condition for preventing plaque rupture and associated adverse cardiovascular events in such patients. Sustained developments in molecular and non-molecular imaging technologies have enabled the increasingly specific and sensitive diagnosis of atherothrombosis in animal studies and clinical settings, making these technologies invaluable to patients' health in the future. In the present review, we discuss current progress regarding the non-molecular and molecular imaging of thrombosis in different animal studies and atherosclerotic patients.

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“…5 6 Recent advances in imaging have allowed for greater non-invasive characterisation of plaque features, such as intraplaque haemorrhage (IPH). [6][7][8] As use of these imaging techniques has increased, so too has the identification of patients with mildly stenotic yet vulnerable plaques that are thought to be the culprit lesions in some embolic strokes of undetermined source (ESUS). 5 9 10 As such, the presence of vulnerable or 'unstable' features of carotid plaques is likely an important imaging biomarker in considering interventional measures, even in cases of minimal stenosis.…”

Section: Introductionmentioning

confidence: 99%

Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis

et al. 2021

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ObjectiveTo systematically analyse prior reports of carotid endarterectomy (CEA) performed in cases of ≤50% carotid stenosis in order to understand patient tolerance and potential benefit.MethodsA systematic review and descriptive analysis was performed in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. An English-language search was performed of online databases using librarian-selected search terms. Abstracts were reviewed for relevance which included mention of carotid endarterectomy and stenosis. Prospective or retrospective observational cohort studies that reported series of patients who underwent endarterectomy for minimal (≤50%) luminal stenosis with reported outcomes were included.ResultsSix studies (which included our institutional series) with a total of 143 patients met the inclusion criteria. The weighted mean age at the time of CEA was 72.3 years; 113 (79.0%) were male. 55.8% of patients with available data had recurrent ipsilateral ischaemic events despite medical therapy. Two patients out of 129 with available perioperative data (1.6%) had perioperative MRI findings of acute ischaemic stroke, both within the hemisphere contralateral to the side of CEA. Of the 138 patients with available follow-up (mean, 36 months), none had recurrent ipsilateral ischaemic events.ConclusionsEndarterectomy for symptomatic carotid disease causing ≤50% stenosis may be a potentially beneficial strategy to prevent stroke recurrence. Studies with robust methodology are needed to draw more definitive conclusions in terms of the safety and efficacy of endarterectomy for minimal stenosis with vulnerable features relative to intensive medical therapy.

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Scanning Fiber Angioscopy

Cited by 10 publications

References 51 publications

High-Resolution Scanning Fiber Angioscopy as an Adjuvant to Fluoroscopy During Endovascular Interventions

High-Resolution Scanning Fiber Angioscopy as an Adjuvant to Fluoroscopy During Endovascular Interventions

Molecular Imaging and Non-molecular Imaging of Atherosclerotic Plaque Thrombosis

Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis

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