Scanning electron microscopy of the normal and denervated limb regenerate in the newt, <i>Notophthalmus</i>, including observations on embryonic amphibian limb‐bud mesenchyme and blastemas of fish‐fin regenerates

Géraudie, Jacqueline; Singer, Marcus

doi:10.1002/aja.1001620107

Cited by 16 publications

(8 citation statements)

References 26 publications

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“…The "common blastemal cell" was the most numerous cell type seen in the axolotl accessory blastema (Fig. 3) as was also the case in the newt amputation blastema (Geraudie and Singer, 1981). "Pale cells," likewise, were seen only rarely in the axolotl accessory blastema.…”

Section: Composition Of the Accessory Growthmentioning

confidence: 88%

Accessory limb production by nerve‐induced cell proliferation

Egar

1988

Anat. Rec.

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The deviation of large limb nerves to a more proximal skin wound yielded a high proportion of accessory limb responses in different age groups of Ambystoma mexicanum (axolotls). In some instances the deviated nerve was positioned on skin previously grafted from an animal of different age and pigmentation from that of the host. Grafts were found not to be a necessary prerequisite for accessory limb induction, but the presence of wound epithelium was required. The rule of distal morphogenesis was expressed in reference to the level at which the nerve was cut, not in reference to the wound site where the accessory actually developed. The upper arm proved to be a more favorable site for accessory limb production than the flank or the leg under the conditions of the present experiments, in which little or no damage was done to the underlying muscles. The orientation of the accessory limb was extremely varied despite the uniformity of the surgical procedure.

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Section: Composition Of the Accessory Growthmentioning

confidence: 88%

Accessory limb production by nerve‐induced cell proliferation

Egar

1988

Anat. Rec.

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“…More recent studies with transmission and scanning electron microscopy have suggested the existence of different populations, but it has been unclear if the observed polymorphism reflects different physiological states of the same cell type rather than the existence of different cell phenotypes (Geraudie and Singer, 1981 (Osborn and Weber, 1986;Steinert and Roop, 1988).…”

Section: Progenitor Cells Of the Regenerating And Developing Limbmentioning

confidence: 97%

Cell origin and identity in Limb regeneration and development

Ferretti

Brockes

1991

Glia

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The occurrence of limb regeneration in adult urodele amphibians raises fundamental questions about the relationship between development and regeneration. The use of monoclonal antibodies as cell markers has provided clear evidence that blastemal cells, the progenitor cells of the regenerate, are not the same as limb bud cells in the embryo. For one of these antibodies the distinction has been traced to the relationship between limb regeneration and the nerve supply. Innervation of the limb bud during development appears to establish nerve-dependent growth control for regeneration. The cell markers have also contributed to the problem of how the blastemal cells arise after amputation, although several important questions remain to be answered.

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“…We have developed various techniques: thin sections, vital dyes (de Margerie et al, 2004;Francillon and Castanet, 1985), qualitative and quantitative micro X-rays (Alcobendas and Castanet, 1985;Meunier, 1984), ultrathin sections of extant and fossil non-demineralized tissues (Rimblot-Baly et al, 1995;Zylberberg and Laurin, 2011), MEB (Géraudie and Singer, 1981), electron microscope (Zylberberg and Meunier, 1984). .…”

Section: Ontogenesis Structures and Functions Of The Skeletal Tissuesmentioning

confidence: 99%