Scanning Electron Microscopic Observation of Transverse (Harris) Lines in the Femur and Tibia of Anatomy Cadavers.

Inokuchi, Seiichiro; Egawa, Kaoru; Takiguchi, Reiji; Kasai, Fumihito

doi:10.1537/ase.108.137

Cited by 2 publications

(4 citation statements)

References 13 publications

(7 reference statements)

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“…On macroscopic cross-sectional examination (Figure 4), various morphologies have been observed, including complete ablation of the medullary space; simple fusion of adjacent trabeculae; or a disklike, washer-shaped or annulus-shaped membrane that interrupts the medullary space. 10 Histologically, transverse lines consist of transversely oriented trabeculae spanning the medullary cavity, parallel to the provisional zone of calcification, and perpendicular to the normal, longitudinally directed trabeculae (Figures 2, B and 4). 11 Additional histologic features have been described in microscopic sections superior to, within, and inferior to distal tibia transverse lines.…”

Section: Figurementioning

confidence: 99%

Section: Pathophysiology Structure and Histologymentioning

confidence: 99%

“…On scanning electron microscopy, there were matrix fibers on the surface of trabeculae, suggesting that the Park-Harris line architecture could share features with a compact bone. 10…”

Section: Pathophysiology Structure and Histologymentioning

confidence: 99%

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Park-Harris Lines

Georgiadis

Gannon

2023

J Am Acad Orthop Surg

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Park-Harris lines are radiographically apparent linear opacities that occur in a metaphyseal bone in proximity to a physis. Lines correspond to a temporary interruption of the normally ossifying physis with a sclerotic line corresponding to transversely oriented trabeculae. They were first appreciated in the long bones of diabetic children and have since been described in various metabolic, endocrinologic, infectious, neoplastic, and posttraumatic conditions as well as in response to systemic medications. Park-Harris lines are clinically useful in demarcating notable events in whole-body or individual bone development, in tracking longitudinal growth, or in assessing physeal arrest and responses to its treatment. There remains controversy about whether these lines are pathologic or a component of physiologic development and whether they constitute true “growth arrest” or rather “growth recovery.” In this review, the history, pathophysiology, imaging, and clinical use of Park-Harris lines as well as an anthropological perspective on their utility for studying illness, nutrition, and historical living conditions over time are discussed.

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Section: Figurementioning

confidence: 99%

Section: Pathophysiology Structure and Histologymentioning

confidence: 99%

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Park-Harris Lines

Georgiadis

Gannon

2023

J Am Acad Orthop Surg

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“…Harris Lines (HL) correspond to highly mineralized transversely oriented trabeculae that can present diverse morphologies and a wide range of thicknesses (Ogden,1984; Inokuchi et al,2000; Egawa et al,2001). Visible through radiography, electron microscopy, magnetic resonance and the histological cuts of bones (Harris,1931; Mays,1995; Yao and Seeger,1997; Inokuchi et al,2000), HL form while the bone is growing but can disappear as a result of bone modeling, remodeling, and resorption (Harris,1933; Garn et al,1968b; Grolleau‐Raoux et al,1997). In paleopathology, HL are of special interest because they are one of the few markers of health status that offer a time‐depth perspective on the life of the individual/group studied (Hunt and Hatch,1981; Maat,1984; Hummert and Van Gerven,1985; Byers,1991).…”

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confidence: 99%

Experimental assessment of nutrition and bone growth's velocity effects on Harris lines formation

Alfonso‐Durruty

2011

American J Phys Anthropol

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Harris lines (HL) are radio-opaque transverse lines traditionally associated with stressors that halt or decelerate growth in humans. Harris lines' status as a stress marker is, however, questionable because their association to illness and deficient growth is low and they commonly form in the absence of stress during periods of accelerated growth. To assess Harris line's reliability as a stress marker, this study examined their association with nutritional status and bone growth velocity through an experimental study in rabbits. Forty-five New Zealand White rabbits were divided into: Control (normal laboratory conditions), Experimental-1 (moderately undernourished), and Experimental-2 (periodically fasted) groups during their growth. Variables analyzed included weight, forelimb length, humeral diaphyseal length, diaphyseal growth velocity, and number of Harris lines. Fewer lines were observed by the end of the study among Experimental-1 animals. More Harris lines formed during periods of rapid growth in the absence of nutritional stress. Accordingly, Harris lines are a poor marker of stress. Intrinsic limitations to paleopathological studies can be overcome, but even the most careful attentiveness to multiple stress markers and cultural context will go amiss if the markers used are unreliable.

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Scanning Electron Microscopic Observation of Transverse (Harris) Lines in the Femur and Tibia of Anatomy Cadavers.

Cited by 2 publications

References 13 publications

Park-Harris Lines

Park-Harris Lines

Experimental assessment of nutrition and bone growth's velocity effects on Harris lines formation

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