Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII

Smeland, Sigbjørn; Müller, Christoph; Alvegård, Thor; Wıklund, Tom; Wiebe, Thomas; Björk, Olle; Stenwig, Anna E.; Willén, Helena; Holmström, Teddy; Follerås, Gunnar; Brosjö, Otte; Kivioja, Aarne; Jonsson, Kjell; Monge, Odd R.; Sæter, Gunnar

doi:10.1016/s0959-8049(02)00747-5

Cited by 161 publications

(38 citation statements)

References 66 publications

(51 reference statements)

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“…Male gender has been reported to be associated with poor response to CT, more likelihood of local recurrence and death (up to 4 times) and higher case fatality ratio 3035363738. Others have failed to document favorable prognostic association of female gender 473439…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…Tumors arising in truncal location fare worse in comparison to those located in limbs 730313740. Bielack et al .…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…Bulky tumors have worse outcomes than smaller ones 43036374849. Primary tumor burden may be expressed either as tumor size or volume as determined on preoperative radiologic investigation 5051.…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…However, collapse and/or displacement in the setting of pathologic fracture may lead to inaccurate tumor measurements. Tumors with volume exceeding 150-200 mL have significantly less likelihood of limb salvage, poor response to CT and increased risk of recurrence 43037. Up to 20% OS patients have evidence of metastases at their initial presentation.…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…It is an important therapeutic strategy to reduce tumor bulk, make surgical procedure easier, better the chance of limb salvage, improve opportunity to obtain tumor free margin, increase the number eligible patients for conservative treatment and targeting of micrometastases 4530374248. It is a consistently strong prognostic factor besides stage at presentation.…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

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Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

Wadhwa

2014

IJOO

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Osteosarcoma (OS), the commonest malignancy of osteoarticular origin, is a very aggressive neoplasm. Divergent histologic differentiation is common in OS; hence triple diagnostic approach is essential in all cases. 20% cases are atypical owing to lack of concurrence among clinicoradiologic and pathologic features necessitating resampling. Recognition of specific anatomic and histologic variants is essential in view of better outcome. Traditional prognostic factors of OS do stratify patients for short term outcome, but often fail to predict their long term outcome. Considering the negligible improvement in the patient outcome during the last 20 years, search for novel prognostic factors is in progress like ezrin vascular endothelial growth factor, chemokine receptors, dysregulation of various micro ribonucleic acid are potentially promising. Their utility needs to be validated by long term followup studies before they are incorporated in routine clinical practice.

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Section: Traditional Prognostic Factorsmentioning

confidence: 99%

“…Tumors arising in truncal location fare worse in comparison to those located in limbs 730313740. Bielack et al .…”

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

Section: Traditional Prognostic Factorsmentioning

confidence: 99%

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Osteosarcoma: Diagnostic dilemmas in histopathology and prognostic factors

Wadhwa

2014

IJOO

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Osteosarcoma

Bauer¹

2006

TNM Online

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Primary bone tumors are rare with an incidence of 2 to 3 per million, and of these, high‐grade osteosarcoma is the most common, representing 35% of all bone sarcomas. The typical patient diagnosed with osteosarcoma is male, between the ages of 10 and 20 years, and complains of pain for one to three months. The tumor is most commonly at the metaphysis of a long bone, with a predilection to the knee region. Dramatic improvements in disease‐free (DFS) and overall survival (OS) were demonstrated with the advent of doxorubicin and methotrexate chemotherapy regimes. The current standard of treatment for the patient with osteosarcoma is chemotherapy and resection of the primary tumor, most commonly preserving the limb. Despite the advances in radiological imaging, chemotherapy and surgery, 40 to 50% of patients will develop distant metastases and die of their disease. This chapter discusses the prognostic factors of disease outcome for osteosarcoma patients, specifically disease‐ or tumor‐related factors, host‐related factors, and environment‐ or treatment‐related factors.

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