Scalp lesion: A presenting feature of squamous cell carcinoma of lung

Gupta, Prem Parkash; Gupta, Kamesh; Gulia, Jogender; Agarwal, Dipti; Mehta, Dinesh

doi:10.4103/0973-1482.73364

Cited by 7 publications

(14 citation statements)

References 19 publications

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“…Metastases of the scalp are mostly a late sign of advanced internal malignancies. They may also be the first visible sign of malignancy (17)(18)(19)(20)(21). In the study conducted by Chiu et al (7) metastases of the scalp skin were the third most common malignant lesions (after BCC and SCC) in this location.…”

Section: Discussionmentioning

confidence: 89%

Scalp Lesions Referred For Surgical Procedures: Single-Center 5-year Experience in Southwestern Poland

Chlebicka

Stefaniak

Gawdzik

et al. 2020

In Vivo

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Background/Aim: The head is a body site with a particular predisposition to skin malignancies due to exposure to UV radiation. The aim of the study was to better elucidate the characteristics of skin lesions that develop on the scalp. Patients and Methods: A retrospective review of all excised and histologically assessed lesions of the scalp at a single dermatosurgery unit throughout a fiveyear period was performed. Demographic features and lesion characteristics were compiled and analyzed. Results: Among 5,601 procedures during the analyzed period, 293 were performed on lesions on the scalp area (5.2%) with a mean patient age of 66±19.7 years. The defects were closed, mainly using primary closure, followed by skin grafts, and, least often, flaps (65.1%, 28.5%, 4.9%, respectively). Two thirds of the excised scalp lesions were histologically confirmed as malignant scalp tumors (mostly basal cell carcinomas followed by squamous cell carcinomas). Conclusion: The vast majority of scalp lesions referred for surgical procedures appeared to be malignant. Therefore, dermatologists should pay special attention to the scalp by examining it thoroughly, as the lesions may be hidden by hair. The head is a body site with a particular predisposition to skin malignancies (1-3). This is due to its frequent exposure to ultraviolet radiation (UV). Tumors in the area of the scalp may be overlooked due to long hair or their occipital or postauricular location. Additionally, UV exposure of the frontal area as well as other scalp areas in patients with androgenetic alopecia is very high (1, 3). This study aimed to provide the characteristics of a group of subjects treated at the Dermatosurgery Unit of the Department of Dermatology, Venereology and Allegrology of Wroclaw Medical University in Poland for scalp lesions with particular reference to age, sex, amount, location and surgical methods of treatment.

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Section: Discussionmentioning

confidence: 89%

Scalp Lesions Referred For Surgical Procedures: Single-Center 5-year Experience in Southwestern Poland

Chlebicka

Stefaniak

Gawdzik

et al. 2020

In Vivo

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“…Women were more represented with the 53.7% (66/123) of cases, compared to the 46.3% (57/123) of men . Median age of AN at onset was 59 (IQR: 47–68).…”

Section: Resultsmentioning

confidence: 99%

“…According to gender distribution of primary tumours, we obviously found that the 100% of patients with uterus cancer (8/ 8) 64,65,84 while in 24.8% (30/121) cases, the diagnosis was synchronous. 7,8,18,20,23,31,33,35,44,46,48,56,68,69,72,73,[76][77][78]81,84,87,93,95,96,99,102,110,111 The specific sites of primary tumours in each of these subgroups were reported in Table S1 (Supporting Information). Considering cases diagnosed after the primary tumour, they were mainly derived from breast and GI cancers (18/88 cases each); synchronous cases prevalently had a GI origin (10/30 cases), while cases diagnosed before the primary tumour were only three (one from GI, namely one thyroid and one lung cancer).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

“…Regarding clinical appearance, AN was identified as a nodule, plaque and patch in 58% (69/119), 8,9,21,22,24,27,33,34,37-41,43,44,46,47,49- 2,6,7,11,[14][15][16][17][18][19][20]23,25,29,67,96 respectively; under the general term of a 'mass' in 16.8% (20/119) 28,32,35,42,45,48,58,59,71,73,80,81,83,87,95,106,110,111,114,117 and as an 'excoriated lesion' in 2.5% (3/119) of cases. 69,78,109 Specifically, breast cancer was mainly associated with patch lesions (9/20), followed by plaques and nodules (five and five out of 20, respectively).…”

Section: Demographic and Epidemiologic Datamentioning

confidence: 99%

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Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Paolino

Pampena

Grassi

et al. 2019

Acad Dermatol Venereol

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Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression‐free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.

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“…Scalp metastasis as the initial manifestation of an underlying lung cancer is an exceedingly rare clinical entity. [19][20][21][22] Small-cell lung cancer accounts for 10% to 15% of all lung cancers. 23 It is characterized by an aggressive clinical course, early systemic dissemination, and increased sensitivity to chemotherapy and radiation.…”

Section: Discussionmentioning

confidence: 99%

Scalp Metastasis as the First Sign of Small-Cell Lung Cancer: Management and Literature Review

Salemis

Veloudis

Spiliopoulos

et al. 2014

International Surgery

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Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 10% among various series. However, the presence of cutaneous metastasis as the first sign of a clinically silent visceral cancer is exceedingly rare. We describe here a case of an asymptomatic male patient who presented with a solitary scalp metastasis as the initial manifestation of an underlying small-cell lung cancer. Diagnostic evaluation revealed advanced disease. We conclude that the possibility of metastatic skin disease should always be considered in the differential diagnosis in patients with a history of smoking or lung cancer presenting with cutaneous nodules. Physicians should be aware of this rare clinical entity, and appropriate investigation should be arranged for early diagnosis and initiation of the appropriate treatment. The prognosis for most patients remains poor.

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Scalp lesion: A presenting feature of squamous cell carcinoma of lung

Cited by 7 publications

References 19 publications

Scalp Lesions Referred For Surgical Procedures: Single-Center 5-year Experience in Southwestern Poland

Scalp Lesions Referred For Surgical Procedures: Single-Center 5-year Experience in Southwestern Poland

Alopecia neoplastica as a sign of visceral malignancies: a systematic review

Scalp Metastasis as the First Sign of Small-Cell Lung Cancer: Management and Literature Review

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