Scalp hair and urine mercury content of children in the Northeast United States: The New England Children's Amalgam Trial

Dunn, Julie E.; Trachtenberg, Felicia; Barregård, Lars; Bellinger, David C.; McKinlay, Sonja M.

doi:10.1016/j.envres.2007.08.015

Cited by 38 publications

(27 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Creatinine excretion was higher for boys compared to girls (P≤0.03) (Trachtenberg and Barregard, 2007). Mercury and NAG did not vary significantly by gender (Trachtenberg and Barregard, 2007, Dunn et al, 2008). …”

Section: Resultsmentioning

confidence: 87%

“…The excretion of creatinine and γ-GT increased significantly with age (P<0.001) (Trachtenberg and Barregard, 2007), while mercury excretion decreased with age (P=0.01) (Dunn et al, 2008). Albumin, NAG, and A1M did not significantly change with age (Trachtenberg and Barregard, 2007).…”

Section: Resultsmentioning

confidence: 99%

“…To develop these recommendations, we use findings from the New England Children’s Amalgam Trial (NECAT), a large, racially diverse sample of healthy children prospectively followed for 5 years. This article highlights results from five previous NECAT publications (Trachtenberg and Barregard, 2007, Trachtenberg and Barregård, in press, Trachtenberg et al, 2008, Trachtenberg et al, 2009, Dunn et al, 2008) with practical suggestions to aid in design of epidemiological studies to collect urine samples to measure mercury levels or renal function.…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage

et al. 2010

Self Cite

View full text Add to dashboard Cite

Objective to provide recommendations for design and analysis of studies using urine specimens to evaluate renal function or mercury excretion in children. Methods analysis of mercury, albumin, γ-GT, NAG concentrations. Results Mercury concentration and creatinine-corrected renal markers were higher in daytime vs. overnight samples. Excretion rates increased with urinary flow rate. γ-GT and NAG concentrations decreased with storage time at −20°C. Differences by age, sex, and race were noted. Conclusions We recommend use of these creatinine-corrected markers and collection of timed overnight urine samples, stored at −70°C, with control for urinary flow rate, age, sex, and race in statistical models.

show abstract

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…For example, Dunn et al (2008) examined US children over a 5-year period and found that the a Exposure was measured by counting the number of restorations using amalgam then an exposure score was computed by first giving scores of 1.0, 2.0, or 3.0 for small, medium, or large restorations, respectively, then adding these scores for each restoration of each tooth. Exposure for baby teeth was taken to be one half the exposure for adult teeth (i.e., 0.5, 1.0, 1.5 for small, medium, and large restorations).…”

Section: Discussionmentioning

confidence: 99%

A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children’s dental amalgam trial

Geier¹,

Carmody²,

Kern

et al. 2010

Biometals

View full text Add to dashboard Cite

Previous studies noted specific changes in urinary porphyrin excretion patterns associated with exposure to mercury (Hg) in animals and humans. In our study, urinary porphyrin concentrations were examined in normal children 8-18 years-old from a reanalysis of data provided from a randomized, prospective clinical trial that was designed to evaluate the potential health consequences of prolonged exposure to Hg from dental amalgam fillings (the parent study). Our analysis examined dose-dependent correlations between increasing Hg exposure from dental amalgams and urinary porphyrins utilizing statistical models with adjustments for the baseline level (i.e. study year 1) of the following variables: urinary Hg, each urinary porphyrin measure, gender, race, and the level of lead (Pb) in each subject's blood. Significant dose-dependent correlations between cumulative exposure to Hg from dental amalgams and urinary porphyrins associated with Hg body-burden (pentacarboxyporphyrin, precoproporphyrin, and coproporphyrin) were observed. Overall, 5-10% increases in Hg-associated porphyrins for subjects receiving an average number of dental amalgam fillings in comparison to subjects receiving only composite fillings were observed over the 8-year course of the study. In contrast, no significant correlations were observed between cumulative exposure to Hg from dental amalgams and urinary porphyrins not associated with Hg body-burden (uroporphyrin, heptacarboxyporphyrin, and hexacarboxyporphyrin). In conclusion, our study, in contrast to the no-effect results published from the parent study, further establishes the sensitivity and specificity of specific urinary porphyrins as a biomarker for low-level Hg body-burden, and also reveals that dental amalgams are a significant chronic contributor to Hg body-burden.

show abstract

“…122,124,125,141,156,176,177 Dental amalgam raises the body burden of mercury, but may not to lead to clinically observable symptoms in children.…”

Section: Diagnosis Of Mercury Intoxicationmentioning

confidence: 99%

Mercury Exposure and Children's Health

Blüml¹,

McCarty

Steckling³

et al. 2010

Current Problems in Pediatric and Adolescent Health Care

416

222

View full text Add to dashboard Cite

Acute or chronic mercury exposure can cause adverse effects during any period of development. Mercury is a highly toxic element; there is no known safe level of exposure. Ideally, neither children nor adults should have any mercury in their bodies because it provides no physiological benefit. Prenatal and postnatal mercury exposures occur frequently in many different ways. Pediatricians, nurses, and other health care providers should understand the scope of mercury exposures and health problems among children and be prepared to handle mercury exposures in medical practice. Prevention is the key to reducing mercury poisoning. Mercury exists in different chemical forms: elemental (or metallic), inorganic, and organic (methylmercury and ethyl mercury). Mercury exposure can cause acute and chronic intoxication at low levels of exposure. Mercury is neuro-, nephro-, and immunotoxic. The development of the child in utero and early in life is at particular risk. Mercury is ubiquitous and persistent. Mercury is a global pollutant, bio-accumulating, mainly through the aquatic food chain, resulting in a serious health hazard for children. This article provides an extensive review of mercury exposure and children’s health.

show abstract

Scalp hair and urine mercury content of children in the Northeast United States: The New England Children's Amalgam Trial

Cited by 38 publications

References 26 publications

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage

Methodological considerations with the use of urine samples for assessment of mercury excretion and markers of renal damage

A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children’s dental amalgam trial

Mercury Exposure and Children's Health

Contact Info

Product

Resources

About