Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study

Davis, Michael; Piliang, Melissa; Bergfeld, Wilma F.; Caterino, Tamara L.; Fisher, Brian K.; Sacha, Jarek; Carr, G.J.; Moulton, Laura T; Whittenbarger, Deborah J; Punyani, Supriya; Schwartz, James R.

doi:10.1111/ics.12737

Cited by 6 publications

(5 citation statements)

References 26 publications

(41 reference statements)

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“…Premature hair loss can be initiated as a result of excessive scalp oxidative stress [8,9]. Thus, a proven approach for improving hair retention from shampoos is the delivery of benefit agents that reduce scalp, and consequently hair, oxidative stress [17,29]. A new shampoo formulation technology has been developed to increase the efficiency of benefit agent delivery, which has demonstrated improved delivery of one such benefit agent, piroctone olamine, to the scalp and follicle [16].…”

Section: Discussionmentioning

confidence: 99%

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Follicular Delivery of Caffeine from a Shampoo for Hair Retention

et al. 2023

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A key factor in the prevention of hair loss is the provision of optimal conditions on the scalp. In this regard, reduction of oxidative stress on the scalp is one critical requirement to support the hair follicles to function optimally. Recently, a novel shampoo formulation technology containing anti-oxidants such as piroctone olamine has been demonstrated to improve hair retention based on micellar degradation and coacervation effects. Caffeine has also been shown to exhibit anti-oxidant activity including the ability to inhibit lipid peroxidation. As with piroctone olamine, it is expected that follicular delivery of caffeine will enhance its anti-oxidant activity in a region that will be beneficial for hair retention. In this study, two shampoo formulations as well as a control formulation were applied to the calf area of n = 9 male participants. The technique of differential tape stripping was applied to obtain the caffeine penetrated to the stratum corneum and to the hair follicles. Isotope-dilution liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was performed to demonstrate caffeine follicular delivery from the shampoo formulas. The results showed that the percentage of caffeine recovered in the hair follicles was 8–9% of the caffeine absorbed into the skin and matched an existing caffeine-based shampoo. In conclusion, a novel shampoo formulation technology has been developed that effectively delivers beneficial anti-oxidants to improve hair retention. This new shampoo is expected to be especially useful in the goal of retaining hair during aging.

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Section: Discussionmentioning

confidence: 99%

“…The advanced delivery technology was shown to effectively deliver piroctone olamine to the scalp surface as well as the hair follicle. This material was shown to reduce scalp oxidative stress and was also demonstrated to improve hair retention [17].…”

Section: Introductionmentioning

confidence: 99%

Follicular Delivery of Caffeine from a Shampoo for Hair Retention

et al. 2023

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“…The results illustrate the effectiveness of a cosmetic antioxidant to improve scalp condition thereby improving hair retention. (52) In a clinical trial carried out by Philippe G Humbert on Topical ascorbic acid on photo aged skin. The results of this clinical trial confirm that topical application of 5% vitamin C over 6 months significantly improves the clinical appearance of photodamaged skin as compared to vehicle alone.…”

Section: Dermatological Conditionsmentioning

confidence: 99%

Current Status of Antioxidants in clinical practices - A Review

Anjali Suryakant Bhure,

Abhijeet Joshi,

Rajat Khanavkar

et al. 2023

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Rationale: Now a days, prescribing antioxidant drugs has become very much common. Their usefulness in certain long term, chronic conditions where oxidative stress plays a vital role is well explained. But in many other conditions, their role is yet not fully discovered or explained as well their duration of use, type of antioxidant to be used, their pros and cons as well as role of free radicals in our body need to be understood by the prescribing physicians. Up to date research on this and knowledge will change attitude and practice and therefore will have positive impact on physical, mental and economic wellbeing of the patients. Aim: It is to study the use of antioxidants in clinical practice and analyze the rationality in terms of their appropriate use, duration, cost, safety and efficacy. Methodology: This review article has been prepared by going through various literature like research articles, text books and drug indexes available on the same topic. This review article focuses on various research on the pharmacological activities of natural and synthetic antioxidant molecules as well as addresses their rationality in current practice. Discussion and Conclusion: Free radicals (FR) are atoms or molecules with unpaired electrons. Endogenous production of free radicals takes place in mitochondria, peroxisomes, endoplasmic reticulum, etc. Exogenous factors like cigarette smoking, chronic alcohol intake, toxic environmental products, etc. also contribute to the production of FR. When pro-oxidative processes overwhelm cellular antioxidant defense, there is a development of oxidative stress. Antioxidants protect cells from damages caused by free radicals. Antioxidants act as free radical scavengers and further classified into endogenous & exogenous antioxidants. Antioxidants prolong or delay the occurrence of neurodegenerative disorders, eye diseases, liver diseases, cancer and ageing. Also, antioxidants are found useful in some dermatological conditions, endometriosis and periodontitis. But studies conducted throughout world shows that free radicals are harmful but are also important in human body for many physiological processes and antioxidants though considered protective and useful may have their own harmful effects. So a balance has to be maintained to get a positive outcome in clinical practice

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“…2 Studies on the use of antioxidants as components of shampoo and leave-on treatment also proved their benefits in improving scalp condition and hair shedding. 17,18 Despite their potency, these drugs are linked to several adverse events such as skin irritation, pruritus, edema, angina pectoris, weight gain, sexual dysfunction, and hypogonadism in males, as well as teratogenic effects in pregnant women. 2,19 Given the potential drawbacks associated with conventional treatments, it is crucial to explore alternative therapies that mitigate side effects while effectively addressing the underlying causes of hair loss.…”

Section: Introductionmentioning

confidence: 99%

“…This plant is recognized for its various pharmacological activities attributed to the presence of a wide range of phytochemicals in its different plant parts. Ethnobotanical studies in the Philippines have documented the folkloric use of C. papaya in the treatment of gastrointestinal disorders (fruit, root), [18][19][20][21] dengue (leaf, flowers), skin problems (leaf ), 22,23 wounds, 24 rheumatism (leaf ), 20,25 dysmenorrhea (flowers), 23 hypertension, 26 and headaches, 27 among others. In India, the flower paste of C. papaya has hair growth promoting activity.…”

Section: Introductionmentioning

confidence: 99%

Carica papaya Flower Extracts Possess Antioxidant and 5α-reductase Inhibitory Activities

2023

Acta Med Philipp

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Objectives. Carica papaya has been widely used commercially for skin care due to its therapeutic benefits. The potential of its flower to promote hair growth has been traditionally recognized in other countries but not in the Philippines. In this study, we explored the effect of various extracts of C. papaya flower in the biological activities associated with hair loss, including 5α-reductase inhibition and antioxidation, as well as identified the putative compounds present in the most potent extract.Methods. The flowers of C. papaya were macerated separately with ethanol, ethyl acetate, and hexane to obtain their corresponding crude extracts. These extracts were subjected to antioxidant tests via 2,2′-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) assays. The total phenolic and flavonoid contents (TPC and TFC) of the crude extracts were determined, as well as the ability of the extracts to inhibit 5α-reductase. The compounds present in the most potent extract were determined using ultraperformance liquid chromatography quadrupole time of flight mass spectrometer (UPLC/MS-QToF).Results. Ethyl acetate extract displayed significantly higher DPPH activity (0.001755 ± 0.00092 ascorbic acid equivalent antioxidant capacity) and 5α-reductase inhibitory activity (115.18 ± 11.61 mg dutasteride/g) compared to ethanol (DPPH: p=0.0121; 5α-reductase: p=0.0016) and hexane (DPPH: p=0.0038; 5α-reductase: p<0.0001) extracts. Similarly, ethyl acetate extract gave the highest FRAP (0.4842 ± 0.0936 mg ascorbic acid/g) activity, TFC (0.0403 mg quercetin/g), and TPC (0.0463 mg gallic acid/g) among the extracts. Forty-nine compounds were annotated in the ethyl acetate extract, with seven (7) putatively identified as fatty acids (9-hydroxy-10,12-pentadecadienoic acid, 9,12,15-octadecatrienoic acid), hydroxyflavone (5-methylkaempferol), alkaloid (allomatrine), dipeptide derivative (aurantiamide acetate), bufotalinin, and 6β-acetoxy-5-epilimonin based on the Traditional Chinese Medicine Library. Conclusion.These results suggest that local C. papaya flowers can be a source of hair growth-promoting agents via their antioxidant and 5α-reductase inhibitory potential.

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Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8‐week randomized, double‐blind, placebo‐controlled clinical study

Cited by 6 publications

References 26 publications

Follicular Delivery of Caffeine from a Shampoo for Hair Retention

Follicular Delivery of Caffeine from a Shampoo for Hair Retention

Current Status of Antioxidants in clinical practices - A Review

Carica papaya Flower Extracts Possess Antioxidant and 5α-reductase Inhibitory Activities

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