Scalp Abscess Due to Streptomyces cacaoi subsp.
            <i>cacaoi</i>
            , First Report in a Human Infection

Pellegrini, Gerald J.; Graziano, James; Ragunathan, Latha; BHAT, M.A.; Hemashettar, Basavaraj; Brown, June M.

doi:10.1128/jcm.06372-11

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…Another study done on Gordonia by Moser et al, [21] showed susceptibility to Ceftriaxone, Clarithromycin, Linezolid, Amikacin, Amoxicillin-Clavulanate and Ciprofloxacin. Resistance to Ceftriaxone was observed on a study done on Streptomyces [22] which is on the contrary to the current study.…”

Section: Discussioncontrasting

confidence: 99%

Characterization and Antimicrobial Susceptibility of Actinomycetes from TB Smear Negative and Retreatment Patients in Nairobi, Kenya

Njeru¹,

Ndung’u²,

Bii³

2019

JBM

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Actinomycetes are opportunistic pathogens in immunosuppressive patients.Pulmonary actinomycetes infections display symptoms that mimic Mycobacteria tuberculosis and can be misdiagnosed and treated as pulmonary TB. Actinomycetes can be co-infection with tuberculosis leading to delayed or inappropriate treatment. This study aimed to identify and determine antimicrobial susceptibility profiles of Actinomycetes from the sputum of TB smear negative and re-treatment patients referred to TB reference facilities in Kenya. Sputum specimens were collected and direct smears stained with Gram's reagents. Culture was done on Mueller Hinton agar and incubated at 35˚C for two weeks. Identification was done using phenotypic and biochemical procedures. Confirmation of the isolates was done using Polymerase Chain Reaction. A total of 52/385 (14%) Actinomycetes were isolated and subjected to antimicrobial susceptibility testing using broth microdilution method to determine the Minimum Inhibitory Concentration. Nine antibiotics were tested which included: Amikacin, Amoxicillin/Clavulanic acid, Ceftriaxone, Ciprofloxacin, Clarithromycin, Linezolid, Doxycycline, Trimethoprim-Sulfamethoxazole and Gentamycin. Staphylococcus aureus (ATCC 25923) was used as a control. Most of the isolates were susceptible to the test antibiotics. However, four isolates showed multidrug resistance to Ceftriaxone and Clarithromycin with resistance of 11.5% and 26.9% respectively. Gentamycin and Ciprofloxacin showed the highest susceptibility of 100% and 98.1% respectively. The findings of this study confirm that Actinomycetes are significant pathogens in TB smear-negative cases. Although most antibiotics were susceptible, resistance to few antibiotics was observed; hence, there is a need for proper screening of TB smear-negative cases to detect infections by Actinomycetes and also conduct the antimicrobial susceptibility test to determine which antibiotic is effective.

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Section: Discussioncontrasting

confidence: 99%

Characterization and Antimicrobial Susceptibility of Actinomycetes from TB Smear Negative and Retreatment Patients in Nairobi, Kenya

Njeru¹,

Ndung’u²,

Bii³

2019

JBM

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“…cacaoiAB184115 was isolated for the first time in 1932 by Waksman from cacao beans, and then Streptomyces cacaoi strain SU2 JF730119 from marine sediment (Nandhini and Selvam, 2011) and Streptomyces cacaoi subsp. cacaoi strain GU144523 from scalp (Pellegrini, 2012). This is the first record of Streptomyces cacaoi to be isolated from Egyptian soil by selective pretreatments on humic acid vitamin agar media with this comprehensive study of antimicrobial activity, phylogenetic analysis and chemical characteristic of antibiotics components.…”

Section: Minimum Inhibitory Concentration (Mic) Of Bioactive Fractionmentioning

confidence: 99%

Phylogenetic and Antimicrobial Characteristics of a Novel Streptomyces sp. Ru87 Isolated from Egyptian Soil

Amin¹,

Tolba²,

Abolmaaty³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…However, it was resistant to trimethoprim-sulfamethoxazole (cotrimoxazole, COX), showing completely no inhibition zone. This is not so often among streptomycetes, being previously observed only in streptomycete isolate from lung nodule (Kapadia et al, 2007), in Streptomyces cacaoi isolated from scalp abscess (Pellegrini et al, 2012), and in 29% of clinical streptomycete isolates of the study of McNeil (McNeil et al, 1990). Interestingly, the patient had been treated with COX a few years prior to the strain isolation.…”

Section: Discussionmentioning

confidence: 85%

A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response

et al. 2020

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Streptomycetes, typical soil dwellers, can be detected as common colonizers of human bodies, especially the skin, the respiratory tract, the guts and the genital tract using molecular techniques. However, their clinical manifestations and isolations are rare. Recently they were discussed as possible "coaches" of the human immune system in connection with certain immune disorders and cancer. This work aimed for the characterization and evaluation of genetic adaptations of a human-associated strain Streptomyces sp. TR1341. The strain was isolated from sputum of a senior male patient with a history of lung and kidney TB, recurrent respiratory infections and COPD. It manifested remarkably broad biological activities (antibacterial, antifungal, betahemolytic, etc.). We found that, by producing specific secondary metabolites, it is able to modulate host immune responses and the niche itself, which increase its chances for long-term survival in the human tissue. The work shows possible adaptations or predispositions of formerly soil microorganism to survive in human tissue successfully. The strain produces two structural groups of cytotoxic compounds: 28-carbon cytolytic polyenes of the filipin type and actinomycin X2. Additionally, we summarize and present data about streptomycete-related human infections known so far.

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Scalp Abscess Due to Streptomyces cacaoi subsp. cacaoi , First Report in a Human Infection

Cited by 11 publications

References 9 publications

Characterization and Antimicrobial Susceptibility of Actinomycetes from TB Smear Negative and Retreatment Patients in Nairobi, Kenya

Characterization and Antimicrobial Susceptibility of Actinomycetes from TB Smear Negative and Retreatment Patients in Nairobi, Kenya

Phylogenetic and Antimicrobial Characteristics of a Novel Streptomyces sp. Ru87 Isolated from Egyptian Soil

A Human Lung-Associated Streptomyces sp. TR1341 Produces Various Secondary Metabolites Responsible for Virulence, Cytotoxicity and Modulation of Immune Response

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