Scalloping of Duodenal Mucosa in Crohn's Disease

Culliford, Andrea; Markowitz, David; Rotterdam, Heidrun; Green, Peter H. R.

doi:10.1097/00054725-200405000-00015

Cited by 60 publications

(25 citation statements)

References 28 publications

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“…A smooth tubular surface with loss of normal folds, "scalloped folds", a mucosal "mosaic" pattern with bulbar micronodularity are descriptive changes that are often used. "Scalloped folds", however, have also been reported in Crohn's disease with duodenal involvement 36. Similar macroscopic changes have been reported with emerging methodologies including capsule and double-balloon enteroscopy.…”

Section: Role Of Endoscopy In Diagnosissupporting

confidence: 62%

Adult Celiac Disease and Its Malignant Complications

Freeman¹

2009

Gut Liver

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Adult celiac disease is a chronic intestinal disorder that has been estimated to affect up to 1-2% of the population in some nations. Awareness of the disease has increased, but still it remains markedly underdiagnosed. Celiac disease is a pathologically defined condition with several characteristic clinical scenarios that should lead the clinician to suspect its presence. Critical to diagnosis is a documented responsiveness to a gluten-free diet. After diagnosis and treatment, symptoms and biopsy-proven changes may recur and appear refractory to a gluten-free diet. Recurrent symptoms are most often due to poor diet compliance, a ubiquitous and unrecognized gluten source, an initially incorrect diagnosis, or an associated disease or complication of celiac disease. Some patients with persistent symptoms and biopsy-proven changes may not have celiac disease at all, instead suffering from a sprue-like intestinal disease, so-called unclassified sprue, which is a specific entity that does not appear to respond to a gluten-free diet. Some of these patients eventually prove to have an underlying malignant cause, particularly lymphoma. The risk of developing lymphoma and other malignancies is increased in celiac disease, especially if initially diagnosed in the elderly, or late in the clinical course of the disease. However, recent studies suggest that the risk of gastric and colon cancer is low. This has led to the hypothesis that untreated celiac disease may be protective, possibly due to impaired absorption and more rapid excretion of fat or fat-soluble agents, including hydrocarbons and other putative cocarcinogens, which are implicated in the pathogenesis of colorectal cancer.

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Section: Role Of Endoscopy In Diagnosissupporting

confidence: 62%

Adult Celiac Disease and Its Malignant Complications

Freeman¹

2009

Gut Liver

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“…They are encountered in other disease processes, though rarely. Case reports and case series have documented several other causes of these mucosal abnormalities (mainly scalloping) including tropical sprue [32,33], giardiasis, eosinophilic enteritis, and HIV-related diseases [32], Crohn's disease [34], and amyloidosis [35].…”

Section: Endoscopic Findingsmentioning

confidence: 99%

Capsule Endoscopy in Celiac Disease: Diagnosis and Management

Green

Rubin

2006

Gastrointestinal Endoscopy Clinics of North America

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“…The causes of seronegative non-CD (SN-non-CD) are vast ranging from infective, inflammatory, immune-mediated and drug-related 16 17. Such examples include autoimmune enteropathy,20 bacterial overgrowth,16 common variable immunodeficiency,21 Crohn's disease,22 gastroenteritis,23 giardiasis,24 25 graft versus host disease,26 HIV enteropathy,27 mycobacterium tuberculosis,25 28 peptic duodentitis± H. pylori ,17 29–32 radiation enteritis,33 tropical sprue25 34 and Whipple's disease 35. Medications include non-steroidal anti-inflammatory drugs,36–38 azathioprine,39 methotrexate,40 mycophenolate mofetil41 and, most recently, angiotensin-2-receptor-blockers (A2RBs), in particular olmesartan 16 42–45.…”

Section: Introductionmentioning

confidence: 99%