Scaling Up Human Immunodeficiency Virus Screening and Antiretroviral Therapy Among Men Who Have Sex With Men to Achieve the 90-90-90 Targets in China

Zhuang, Xun; Peng, Peng; Sun, Huamin; Chu, Minjie; Jiang, Shengyang; Jiang, Liying; Zhou, Pingyu; Zhu, Bowen; Zhang, Lei

doi:10.1097/olq.0000000000000744

Cited by 10 publications

(10 citation statements)

References 23 publications

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“…A free VL testing was provided to patients once a year, who had received ART for more than 6 months, but 11.8% HIV‐1 infected patients on ART had not conducted VL testing in 2015 6 . A compartmental model was constructed to predict the HIV epidemic in Chinese men who have sex with men (MSM), HIV prevalence would increase from 9.2% to 12.6% during 2016 to 2020, only 49.2% infected MSM would be diagnosed by 2020, to achieve 90‐90‐90 targets by 2020, an extra 850 000 HIV screening tests were needed from 2016 to 2020 7 . To achieve the UNAIDS targets, more feasible HIV VL monitoring approaches are desirable.…”

Section: Introductionmentioning

confidence: 99%

Multicenter evaluation of Xpert HIV‐1 viral load assay for HIV quantification in China

Liu

Deng

Lan

et al. 2020

Journal of Medical Virology

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New approaches to increase HIV‐1 testing and HIV‐1 viral load (VL) monitoring are needed for people living with HIV (PLHIV) in China. The Xpert HIV‐1 VL assay was prequalified by the World Health Organization in 2017 but has not been evaluated in China. A multicenter evaluation was conducted to assess the accuracy of the Cepheid Xpert HIV‐1 VL assay compared to the Abbott RealTime HIV‐1 assay in China. Overall agreement was seen in 558 of 562 specimens (99.29%) with a κ value of 0.962. Pearson's coefficient between the two assays was 0.943. Analyzed by the Bland‐Altman method, the mean bias was −0.54 log10 copies/mL, and 94.05% results fell within the 95% confidence limit of agreement (−1.248 to 0.168 log10 copies/mL). The coefficient of variation of the Cepheid Xpert HIV‐1 VL assay ranged from 0.61% to 1.55%, as determined by testing eight positive plasma specimens with three different lots on different days. Due to its simplicity, random‐access, rapid turnaround time, and accuracy, the Xpert HIV‐1 VL assay can be used in local hospitals and clinics that bear the burden of identifying and treating HIV patients in China.

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Section: Introductionmentioning

confidence: 99%

Multicenter evaluation of Xpert HIV‐1 viral load assay for HIV quantification in China

Liu

Deng

Lan

et al. 2020

Journal of Medical Virology

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“…Although the national HIV prevalence has remained low (< 0.1%) in China, this prevalence has been increasing among men who have sex with men (MSM) [1]. HIV prevalence among MSM increased from 1.5% in 2005 to 8.0% in 2015 [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…It is estimated that 1 out of 70 men could be MSM. If the current HIV epidemic in MSM were not contained, the overall HIV prevalence would increase from 9.2% in 2016 to 12.6% in 2020 and 16.2% in 2025, [1]. Condom use is considered to be one of the most effective intervention strategies [4].…”

Section: Introductionmentioning

confidence: 99%

Driving force of condomless sex after online intervention among Chinese men who have sex with men

Huang

Pan

et al. 2019

BMC Public Health

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Background Condom use remains consistently low among Chinese men who have sex with men (MSM). This study aims to identify factors associated with condom use after online video intervention. Methods This is a secondary data analysis of data collected from an online non-inferiority trial comparing the effectiveness of two condom use promotion video interventions among Chinese MSM. Participants from the two groups were combined since the effectiveness of two video interventions were shown to be non-inferior. Univariable and multivariable logistic regression were used to identify factors associated with condomless sex after the intervention during the follow-up interval. Results Overall, 1173 participants were recruited at baseline and 791 (67.4%) completed the three-month follow-up survey. 57.3% (453/791) of the participants reported condomless sex after intervention in the three-month follow-up interval. MSM who have had sex under the influence of alcohol in the last 3 months (Odds Ratio(OR) = 1.90; 95% CI: 1.22, 2.97; Adjusted OR(AOR) = 1.79; 95% CI: 1.13, 2.83) and ever have had sex tourism (OR = 2.75; 95% CI: 1.34, 5.63; AOR = 2.40; 95% CI: 1.15, 5.07) at baseline were more likely to have condomless sex after intervention in the three-month follow-up period. MSM who had a higher level of community engagement in sexual health (OR = 0.54; 95% CI: 0.35, 0.82; AOR = 0.49; 95% CI: 0.32, 0.75 with substantial engagement) and who viewed additional condom promotion videos during the follow-up period by themselves (OR = 0.67; 95% CI = 0.50, 0.89; AOR = 0.67; 95% CI: 0.50, 0.91). were less likely to have condomless sex during the follow-up period. Conclusion The intervention appeared to be effective among MSM who reported viewing additional condom promotion videos by themselves and more community engagement after the intervention. In MSM who reported risky sexual behaviors at baseline, the intervention appeared less effective. Tailored intervention videos that target particular subgroups, active in-person community engagement, and optimized intervention frequency should be considered in future sexual health interventions. Electronic supplementary material The online version of this article (10.1186/s12889-019-7307-y) contains supplementary material, which is available to authorized users.

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“…Globally, young men who have sex with men (YMSM) represent one of the most at-risk groups for new HIV infection (Beyrer et al, 2012; World Health Organization, 2015), and in China particularly, the HIV epidemic among YMSM is increasing rapidly (Li, Jiang, & Zhang, 2019; Wu, 2018). According to data released by the Chinese Center of Disease Prevention and Control (China CDC), HIV prevalence among MSM had increased from 0.9% in 2003 to 8.0% in 2015 (China National Health and Family Planning Commission, 2016), and if these trends continue unabated, experts estimate that one in six Chinese MSM will be infected by HIV in 2025 (Zhuang et al, 2018). As is true for at-risk MSM globally, condomless anal sex (CAS) represents the primary route of HIV transmission among Chinese YMSM (Li et al, 2019; Wu, 2018; Zhang, Chow, & Wilson, 2012); preexposure prophylaxis (PrEP) has not been adopted in China (Han et al, 2019).…”

mentioning

confidence: 99%

A pilot cultural adaptation of LGB-affirmative CBT for young Chinese sexual minority men’s mental and sexual health.

Pan¹,

Sun²,

Li³

et al. 2021

Psychotherapy

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Young men who have sex with men (YMSM) represent one of the most at-risk groups for HIV infection and experience sexual minority stress especially in high-stigma settings, which affects their psychological health and increases likelihood of HIV-risk behaviors. The HIV epidemic in China is increasing rapidly among YMSM. However, no evidence-based intervention has specifically targeted Chinese YMSM's minority stress to improve their mental and sexual health. Adaptation of evidence-based interventions to promote the mental and sexual health of YMSM is one promising way to achieve the global target of HIV epidemic control. The current adaptation study followed the Assessment-Decision-Administration-Production-Topical Experts-Integration-Training-Testing model. YMSM (n ϭ 41) and key stakeholders (n ϭ 16) in China provided feedback into the selected intervention, a cognitive-behavioral therapy called Effective Skills to Empower Effective Men, originally developed with efficacy in the United States. An open pilot (n ϭ 8) was also then conducted. Qualitative and quantitative data collected from each adaptation phase were analyzed to form the adapted intervention: "Yi Si Tang (益思堂)." Adaptations addressed a cultural context prioritizing family needs, limited support from the health system, as well as YMSM delivery preferences. YMSM and key stakeholders deemed the intervention acceptable and preliminarily feasible for the Chinese context. The pre-post comparison of mental and sexual health outcomes indicated improvement in mental health and sexual health of Chinese YMSM. Outcomes of the small initial pilot suggest future promise for this first-of-its-kind intervention for Chinese YMSM.

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Scaling Up Human Immunodeficiency Virus Screening and Antiretroviral Therapy Among Men Who Have Sex With Men to Achieve the 90-90-90 Targets in China

Abstract: Achieving the 90-90-90 targets by 2020 requires steep increase in investment, but delaying the targets to 2025 is practical and cost-effective.

Cited by 10 publications

References 23 publications

Multicenter evaluation of Xpert HIV‐1 viral load assay for HIV quantification in China

Multicenter evaluation of Xpert HIV‐1 viral load assay for HIV quantification in China

Driving force of condomless sex after online intervention among Chinese men who have sex with men

A pilot cultural adaptation of LGB-affirmative CBT for young Chinese sexual minority men’s mental and sexual health.

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