Scaling models for microfabricated in vivo neural recording technologies

Scholvin, Jörg; Fonstad, Clifton G.; Boyden, Edward S.

doi:10.1109/ner.2017.8008321

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compatibility with state of the art electronics, including those that can be sourced from modern semiconductor foundries, is a key advantage. The dual-sided geometry allows scaling to small electrodes at high area fill factors, with geometric layouts that do not depend on the area coverage of the supporting electronics (41,42). Mechanically flexible platforms of this sort offer many advantages compared with alternative systems for electrophysiology, with potential uses in neuroscience, cardiac science, and other areas.…”

Section: Discussionmentioning

confidence: 99%

Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology

Song

Chiang

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Materials and structures that enable long-term, intimate coupling of flexible electronic devices to biological systems are critically important to the development of advanced biomedical implants for biological research and for clinical medicine. By comparison with simple interfaces based on arrays of passive electrodes, the active electronics in such systems provide powerful and sometimes essential levels of functionality; they also demand long-lived, perfect biofluid barriers to prevent corrosive degradation of the active materials and electrical damage to the adjacent tissues. Recent reports describe strategies that enable relevant capabilities in flexible electronic systems, but only for capacitively coupled interfaces. Here, we introduce schemes that exploit patterns of highly doped silicon nanomembranes chemically bonded to thin, thermally grown layers of SiO as leakage-free, chronically stable, conductively coupled interfaces. The results can naturally support high-performance, flexible silicon electronic systems capable of amplified sensing and active matrix multiplexing in biopotential recording and in stimulation via Faradaic charge injection. Systematic in vitro studies highlight key considerations in the materials science and the electrical designs for high-fidelity, chronic operation. The results provide a versatile route to biointegrated forms of flexible electronics that can incorporate the most advanced silicon device technologies with broad applications in electrical interfaces to the brain and to other organ systems.

show abstract

Section: Discussionmentioning

confidence: 99%

Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology

Song

Chiang

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Even if techniques such as e‐beam lithography were employed to further reduce the dimension of the wire, its impedance would start causing issues with the quality of the recording. [ 71 ] Second, there are only a few solutions for digitizing signals (e.g., Intan Technologies, Multichannel Systems, White Matter) from more than 128 electrodes, making their simultaneous recording highly challenging. The scarcity of solutions is even worse if one wants to operate with transistor arrays, for which one needs to manually build the readout electronics as no commercial solution exists to our knowledge.…”

Section: Next Generation Devicesmentioning

confidence: 99%

Toward the Next Generation of Neural Iontronic Interfaces

Forró

Musall

Montes³

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Neural interfaces are evolving at a rapid pace owing to advances in material science and fabrication, reduced cost of scalable complementary metal oxide semiconductor (CMOS) technologies, and highly interdisciplinary teams of researchers and engineers that span a large range from basic to applied and clinical sciences. This study outlines currently established technologies, defined as instruments and biological study systems that are routinely used in neuroscientific research. After identifying the shortcomings of current technologies, such as a lack of biocompatibility, topological optimization, low bandwidth, and lack of transparency, it maps out promising directions along which progress should be made to achieve the next generation of symbiotic and intelligent neural interfaces. Lastly, it proposes novel applications that can be achieved by these developments, ranging from the understanding and reproduction of synaptic learning to live‐long multimodal measurements to monitor and treat various neuronal disorders.

show abstract

“…We utilize our close-packed 2-D probe technology of [ 12 ] as the unit building block for our 3-D arrays. With probe designs scaling possibly into the thousands of recording sites and beyond [ 41 ], the close-packed recording sites can be of benefit in automating the large-scale data analysis that will be necessary when recording from a large number of sites across many brain regions.…”

Section: Introductionmentioning

confidence: 99%

Scalable, Modular Three-Dimensional Silicon Microelectrode Assembly via Electroless Plating

et al. 2018

View full text Add to dashboard Cite

We devised a scalable, modular strategy for microfabricated 3-D neural probe synthesis. We constructed a 3-D probe out of individual 2-D components (arrays of shanks bearing close-packed electrodes) using mechanical self-locking and self-aligning techniques, followed by electroless nickel plating to establish electrical contact between the individual parts. We detail the fabrication and assembly process and demonstrate different 3-D probe designs bearing thousands of electrode sites. We find typical self-alignment accuracy between shanks of <0.2° and demonstrate orthogonal electrical connections of 40 µm pitch, with thousands of connections formed electrochemically in parallel. The fabrication methods introduced allow the design of scalable, modular electrodes for high-density 3-D neural recording. The combination of scalable 3-D design and close-packed recording sites may support a variety of large-scale neural recording strategies for the mammalian brain.

show abstract

Scaling models for microfabricated in vivo neural recording technologies

Cited by 5 publications

References 17 publications

Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology

Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology

Toward the Next Generation of Neural Iontronic Interfaces

Scalable, Modular Three-Dimensional Silicon Microelectrode Assembly via Electroless Plating

Contact Info

Product

Resources

About