2020
DOI: 10.1007/s41981-019-00060-x
|View full text |Cite
|
Sign up to set email alerts
|

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
49
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 63 publications
(52 citation statements)
references
References 103 publications
0
49
0
Order By: Relevance
“…The ultimate goal of research and development (small scale, typically on the order of mg to 1 kg) is production (large scale, typically on the order of 10 kg and higher). There are several options for scaling a continuous process from lab to plant [7,115]: 1) running for a longer period of time; 2) scaling-out (numbering up/ parallelization); 3) scaling-up (increasing size). A combination of scaling-out and scaling-up is not uncommon for commercial-scale production, because the middlesized reactor can still benefit from enhanced heat transfer and safety, without any further re-optimization [7].…”
Section: Scaling-upmentioning
confidence: 99%
See 1 more Smart Citation
“…The ultimate goal of research and development (small scale, typically on the order of mg to 1 kg) is production (large scale, typically on the order of 10 kg and higher). There are several options for scaling a continuous process from lab to plant [7,115]: 1) running for a longer period of time; 2) scaling-out (numbering up/ parallelization); 3) scaling-up (increasing size). A combination of scaling-out and scaling-up is not uncommon for commercial-scale production, because the middlesized reactor can still benefit from enhanced heat transfer and safety, without any further re-optimization [7].…”
Section: Scaling-upmentioning
confidence: 99%
“…As described by Berton et al [115], a major concern during the scaling-up process is insufficient heat transfer, especially for fast reaction types such as nitration, organolithium, Grignard and reduction. The limitations of heat transfer within the continuous reactors are (see Fig.…”
Section: Scaling-upmentioning
confidence: 99%
“…Most of them operate via electrolysis and are commercially available. However, with the growing interest in continuous flow operations by the pharmaceutical industry for active pharmaceutical ingredient (API) manufacturing and the accompanied demand to access new process windows, 6 custom-built generators for explosive, toxic, and short-lived reagents are constantly being developed. Both the now common access to flow equipment and technological advances in this field led to the emergence of a new generation of chemical generators.…”
Section: Chemical Generators For Hazardous Reagentsmentioning
confidence: 99%
“…Furthermore, students can get insight in the importance of fundamental transport phenomena, like mass and heat transport. This is especially important for multiphase reaction conditions (gas-liquid or liquid-liquid biphasic reactions) or for exothermic reactions, two notoriously challenging examples to execute and to scale in both academia and industry [32].…”
Section: Introductionmentioning
confidence: 99%