Scale-Up Studies on Styrene−Butyl Methacrylate Copolymerization Reaction

Abstract

The scale-up of the radical-initiated copolymerization of styrene with butyl methacrylate is studied here. The reaction is scaled up from 3 to 100 L scale. The problems encountered during the scale-up are agglomeration, foaming, and material loss. The techniques employed to overcome these problems are discussed in detail. Kinetic studies indicate that the reaction exhibits autoacceleration behaviour, with induction time varying with reactor size. The effects of initiator concentration and reactor size on the molecular weight and melt flow index of the final sample are also studied.

Synthesis of Cyclodextrin-Grafted Chitosan: From Laboratory Scale to Pilot Scale

“…29 Moreover, the styrene-butyl methacrylate copolymerization reaction was successfully scaled up from 3 to 10 and 100 L reactors by maintaining a constant Reynolds number. 30 In addition to the scaling-up strategy, the appropriate metric for measuring the scaling-up success is also crucial. In the scaleup process of traditional chemicals, the product formation rate is often utilized as a critical metric.…”

“…For aerobic fungal fermentation, the energy dissipation/circulation function (EDCF) provided identical results between laboratory and commercial scale . Moreover, the styrene-butyl methacrylate copolymerization reaction was successfully scaled up from 3 to 10 and 100 L reactors by maintaining a constant Reynolds number …”