Scale-up strategies for solid state fermentation systems

Lonsane, B. K.; Saucedo‐Castañeda, Gerardo; Raimbault, Maurice; Roussos, Sévastianos; Viniegra‐González, Gustavo; Ghildyal, N. P.; Ramakrishna, M.; Krishnaiah, Maddeboina

doi:10.1016/0032-9592(92)85011-p

Cited by 170 publications

(65 citation statements)

References 49 publications

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“…Problems commonly associated with SSF are heat build-up, bacterial contamination, scale-up, biomass growth estimation, and control of substrate moisture content (Lonsane et al 1985). At this stage, engineering aspects come into play and the success of scale-up will depend on bioreactor design and operation (Lonsane et al 1992).…”

Section: Biotechnological Application Of Lignocellulose and Its Biodementioning

confidence: 99%

Lignocellulose biodegradation: Fundamentals and applications

Malherbe

Cloete

2002

Rev Environ Sci Biotechnol

390

163

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Section: Biotechnological Application Of Lignocellulose and Its Biodementioning

confidence: 99%

Lignocellulose biodegradation: Fundamentals and applications

Malherbe

Cloete

2002

Rev Environ Sci Biotechnol

390

163

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“…While most of the researchers have used a low mixing speed (1-15 rpm), some have used high rates of rotation. Different results have been reported by different authors (Silman, 1980;Kargi and Curme, 1985;Lonsane, 1987, 1988;Mitchell et al, 1988;Lonsane et al, 1992b). Therefore, it is necessary to study agitation and analyze its effects particularly for a determinate process.…”

Section: Effect Of Different Mixing Interval On Xylanase Productionmentioning

confidence: 98%

Governing parameters on xylanase production using developed bioreactor

Lee¹,

Demirtaş²,

Omar³

2015

MJM

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Aims: Chemicals bleaching are common steps in pulp and paper manufacturing process. The reduction of chemical use would result in lower waste treatment costs while minimizes the impact on the environment. This can be achieved using enzyme (xylanase). Compared to submerged fermentation process, the cost for enzyme production is much cheaper using solid state fermentation process (SSF). The present study aimed to examine factors affect xylanase production using developed SSF bioreactor. Methodology and results:The performance of developed bioreactor namely FERMSOSTAT had been investigated in xylanase production studies. In this studies, local isolate Aspergillus niger USM AI 1 was used together with sugarcane bagasse and palm kernel cake (ratio 1:1), which serve as substrates for xylanase production. The highest xylanase activity and production of 397 U/g and 103 U/mgG glucosamine were obtained, respectively when the fermentation process was carried out under examined enzyme production conditions of 0.5 kg substrate; 70% (w/w) moisture content; 30 °C; aeration at 4 L/h.g fermented substrate for 5 min and mixing at 0.5 rpm for 5 min. On the other hand, compared to initial SSF conditions for xylanase production, xylanase activity increased 681% after all factors affect xylanase production have been examined. Conclusion, significance and impact of study: The performance of the newly developed bioreactor is good since it can be used to produce xylanase with high title when compared with previous researcher findings.

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“…The substrates were mixed by hand and transfer into the fermenter (FERMSOSTAT) through the substrate port located on the top of the fermenter vessel. The substrate was pre-treated cum sterilized in situ with hot air sterilization at 130 °C for 3 h (Lonsane et al, 1992). After the sterilization process, the fermenter and substrates were allowed to cool down to ambient temperature before inoculation of the substrates were carried out.…”

Section: Substrates Preparation and Sterilizationmentioning

confidence: 99%

Investigation of newly developed solid state fermenter on carboxymethyl cellulase production

Lee¹,

Demirtaş²,

Omar³

2013

MJM

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Aims: Enzyme (cellulase) contributes 10% to overall cost in bioethanol production from lignocellulosic biomass. This means that the cost for bioethanol production will be reduced if cellulase can be produced using cheaper method. Compared with submerged fermentation, it is recognized that the cost for cellulase production using solid state fermentation (SSF) process is much cheaper. The present study aimed to optimize cellulase production via SSF process using agro-industrial residual as substrate. Methodology and result: Newly developed solid state bioreactor, FERMSOSTAT had been evaluated in cellulase production using local isolate Aspergillus niger USM AI 1 grown on sugarcane baggase and palm kernel cake as substrates at 1:1 (w/w) ratio. Under optimized SSF conditions of 0.5 kg substrate; 70% (w/w) moisture content; 30 °C; aeration at 4 L/h.g fermented substrate for 5 min and mixing at 0.5 rpm for 5 min, about 62.6 U/g of CMCase activity obtained. At the same time, comparative studies of the enzyme production under the same SSF conditions indicated that CMCase produced by Trichoderma reesei was about 9% lower compared with A. niger USM AI 1. Conclusion, significance and impact of study: It can be concluded that the performance of newly developed SSF fermenter is good since it can used to produce CMCase enzyme with reasonable good title (863% increased in CMCase production after optimization). Thus, this newly developed SSF bioreactor has highly potential be used as prototype for larger scale bioreactor design.

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Scale-up strategies for solid state fermentation systems

Cited by 170 publications

References 49 publications

Lignocellulose biodegradation: Fundamentals and applications

Lignocellulose biodegradation: Fundamentals and applications

Governing parameters on xylanase production using developed bioreactor

Investigation of newly developed solid state fermenter on carboxymethyl cellulase production

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