Scale up in preparative chromatography

Heuer, Christian; Hugo, P.; Mann, Gregor; Seidel‐Morgenstern, A.

doi:10.1016/s0021-9673(96)00496-7

Cited by 66 publications

(36 citation statements)

References 11 publications

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“…The second cycle is sufficient to achieve an almost complete separation. Also, for other experimental conditions (varied were the amount injected, the composition of the feed mixture, the volumetric flow rate, i.e., the linear velocity and the column dimensions [16] The results obtained in separating the two isomers demonstrate the applicability of the described dispersion model in combination with the experimentally determined adsorption isotherms and stage numbers and the formulated boundary conditions for the quantitative description of different types of liquid chromatographic processes. Similar good results, which are not presented here, were obtained for another experimental example in verifying the model for predicting product purities using the SMB process [14].…”

Section: Accuracy Of the Modelmentioning

confidence: 73%

“…Subsequently, for the elution process and recycling chromatography a comparison between experimental and theoretical chromatograms will be performed. A more detailed presentation of the experiments carried out is given in [16].…”

Section: Methodsmentioning

confidence: 99%

“…To avoid hydrodynamic perturbation around the feed position and to assure a constant velocity in the whole apparatus, the following relation has to be fulfilled by the volumetric flow rates of the feed solution, V Ç F , and the solvent, V Ç S : (16) Usually the adsorption isotherms, q(c), are nonlinear. Thus, there are no analytical solutions available to solve Eqs.…”

Section: Reviewmentioning

confidence: 99%

“…The method allows the application of rather coarse grids leading to fast but accurate calculations [15]. It was already applied several times to successfully calculate concentration profiles in a single column [2,9,16]. The adaptation to simulate multi-column counter-current processes has been reported in detail elsewhere [14].…”

Section: Reviewmentioning

confidence: 99%

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Comparison of Various Process Engineering Concepts of Preparative Chromatography

Heuer¹,

Kniep²,

Falk

et al. 1998

Chem. Eng. Technol.

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Liquid chromatography utilizing porous solid phases (adsorption chromatography) is one of the most powerful and versatile methods of modern analytical chemistry. Its widespread application is due in part to the development of a broad range of combinations of solid stationary and liquid mobile phases. Normal phase and reverse phase chromatography with pure and chemically modified silica, respectively, affinity chromatography, can be cited as examples [1]. In addition to its use as an analytical method, chromatography is becoming increasingly important in the preparative scale for the isolation of pure substances in the pharmaceutical industry, in biotechnology, and in the production of fine chemicals. In many cases, the required purity criteria can only be met with chromatographic techniques, as in the resolution of racemates. From a process engineering viewpoint, a better understanding of concentration profile deformations caused by intended overloading of separation columns has recently been acquired [2]. In particular, this concerns the description of displacement and entrainment effects associated with the competitive adsorption. A series of alternative operating modes has been developed and used [3] to enhance yields and productivities. In spite of a number of attempted comparative studies [4], quantitative information about optimizing these processes is lacking. This article will compare four different process engineering concepts of preparative chromatography on the basis of a uniform theoretical model.

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Section: Accuracy Of the Modelmentioning

confidence: 73%

Section: Methodsmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Heuer¹,

Kniep²,

Falk

et al. 1998

Chem. Eng. Technol.

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“…6 Research related to preparative chromatography parameters such as, size of column, choice of stationary and mobile phase, column packing density and particle size of stationary phase has been carried out. 7 The applications, however, are fairly limited due to the kinds and properties of analytes and stationary phase until now.…”

Section: Introductionmentioning

confidence: 99%

Enantioseparation of Racemic 1,1'Binaphthyl-2,2'diamine by Preparative Liquid Chromatography

2004

Bulletin of the Korean Chemical Society

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The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1'-binaphthyl-2,2'-diamine (4).

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Optimization of Solvent Gradients for Chromatographic Separations

Schramm

Kniep²,

Seidel‐Morgenstern

2001

Chem. Eng. Technol.

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Due to increasing purity requirements, temperature sensitivity and complexity of feed mixtures, chromatographic separations are more and more applied to purify value added products. Frequently, gradient chromatography is used to reduce the duration of batch separations of mixtures with very different retention times of the components. In this case the retention times of the slowly migrating components are reduced by increasing the elution strength of the eluant.

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Scale up in preparative chromatography

Cited by 66 publications

References 11 publications

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Enantioseparation of Racemic 1,1'Binaphthyl-2,2'diamine by Preparative Liquid Chromatography

Optimization of Solvent Gradients for Chromatographic Separations

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