We study the structural constraint of random scale-free networks that determines possible combinations of the degree exponent γ and the upper cutoff kc in the thermodynamic limit. We employ the framework of graphicality transitions proposed by [Del Genio and co-workers, Phys. Rev. Lett. 107, 178701 (2011)], while making it more rigorous and applicable to general values of kc. Using the graphicality criterion, we show that the upper cutoff must be lower than kc ∼ N 1/γ for γ < 2, whereas any upper cutoff is allowed for γ > 2. This result is also numerically verified by both the random and deterministic sampling of degree sequences.PACS numbers: 89.75. Hc, 02.10.Ox, 89.75.Da, 64.60.aq Complex networks [1] are found in diverse natural and artificial systems, which consist of heterogeneous elements (nodes) coupled by connections (links) markedly different from those of ordinary lattices. In particular, many systems [2-6] can be interpreted as scale-free networks, in which the fraction of nodes with degree k (i.e., k links) obeys the power-law distribution P (k) ∼ k −γ over a broad range of values bounded by k m ≤ k ≤ k c where γ is called the degree exponent, k m is the lower cutoff, and k c is the upper cutoff. There have been interests in topological and dynamical properties induced by the degree distribution, which have been examined through various studies on random scale-free networks [7][8][9][10][11][12][13].Random scale-free networks refer to an ensemble of networks constrained only by the parameters γ, k m , and k c . In general, k m is set as a constant, while k c is assumed to increase with the number of nodes N as k c ∼ N α with 0 ≤ α ≤ 1. Besides, self-loops or multiple links between a pair of nodes are often disallowed. Under the circumstances, the degree exponent γ and the cutoff exponent α determine various properties of networks in the thermodynamic limit, N → ∞. It is known that γ contributes to the resilience against node failures [7], the epidemic threshold [8], the consensus time of opinion dynamics [9], etc. Meanwhile, α affects the expected value of the generated maximum degree [10], degree correlations [11], finite-size scaling at criticality [12,13], etc.The studies of random scale-free networks characterized by γ and α must be based on the knowledge that such networks actually exist in the thermodynamic limit. Hence, it is necessary to understand the constraint on the possible values of γ and α. This problem is exactly equivalent to the issue of the graphicality of random scale-free networks. A degree sequence {k 1 , k 2 , . . . , k N } is said to be graphical if it can be realized as a network without self-loops or multiple links. As an indicator of the existence of graphical sequences, the graphicality fractionis defined as the fraction of graphical sequences among the sequences with an even degree sum generated by P (k). Note that the degree sequences with an odd degree sum are left out, since such sequences are trivially nongraphical. The constraint on the possible values of γ and ...