Scale for Ocular motor Disorders in Ataxia (SODA)

Shaikh, Aasef G.; Kim, Ji-Soo; Froment, Caroline; Koo, Yu Jin; Dupré, Nicolas; Hadjivassiliou, Marios; Honnorat, Jérôme; Kothari, Sudhir; Mitoma, Hiroshi; Rodrigue, Xavier; Soong, Bing‐Wen; Subramony, S. H.; Strupp, Michael; Schmahmann, Jeremy D.; Manto, Mario

doi:10.1016/j.jns.2022.120472

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…More recently, standardised evaluation tools have been presented to grasp differential aspects of cerebellar dysfunction, including the cognitive (CCAS scale) and ocular–motor domains (SODA score) [ 9 , 33 ]. In the current study, we were particularly interested in the effects of cerebellar degeneration on cortical structure and function.…”

Section: Discussionmentioning

confidence: 99%

Disability in cerebellar ataxia syndromes is linked to cortical degeneration

Conrad¹,

Huppert²,

Ruehl³

et al. 2023

J Neurol

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Objective We aimed to relate clinical measures of disability in chronic cerebellar degeneration to structural whole-brain changes using voxel-based and surface-based morphometry (vbm and sbm). We were particularly interested in remote effects of cerebellar degeneration in the cerebral cortex. Methods We recruited 30 patients with cerebellar degeneration of different aetiologies (downbeat nystagmus syndrome, DBN n = 14, spinocerebellar ataxia, SCA n = 9, sporadic adult late-onset ataxia, SAOA n = 7). All patients were thoroughly characterised in the motor, cognitive, vestibular and ocular–motor domains. Vbm and sbm were used to evaluate structural differences between cerebellar degeneration patients and a group of healthy age- and gender-matched volunteers. Linear regression models were used to correlate functional measures of disease progression and postural stability with whole brain volumetry. Results Patients with SCA and SAOA showed widespread volume loss in the cerebellar hemispheres and less prominently in the vermis. Patients with DBN showed a distinct pattern of grey matter volume (GMV) loss that was restricted to the vestibular and ocular–motor representations in lobules IX, X and V–VII. Falls were associated with brainstem white matter volume. VBM and SBM linear regression models revealed associations between severity of ataxic symptoms, cognitive performance and preferred gait velocity. This included extra-cerebellar (sub-)cortical hubs of the motor and locomotion network (putamen, caudate, thalamus, primary motor cortex, prefrontal cortex) and multisensory areas involved in spatial navigation and cognition. Conclusion Functional disability in multiple domains was associated with structural changes in the cerebral cortex.

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Section: Discussionmentioning

confidence: 99%

Disability in cerebellar ataxia syndromes is linked to cortical degeneration

Conrad¹,

Huppert²,

Ruehl³

et al. 2023

J Neurol

View full text Add to dashboard Cite

show abstract

“…Each of these syndromes can be assessed clinically with a dedicated rating scale: Scale for Oculomotor Deficits in Ataxias (SODA) scale for the VCS, Schmahmann scale for the CCAS/SS, Scale for the Assessment and Rating of Ataxia (SARA)/ International Cooperative Ataxia Rating Scale (ICARS) for the CMS ( Schmitz-Hübsch et al, 2006 , Shaikh et al, 2022 , Hoche et al, 2018 , Trouillas et al, 1997 ).…”

Section: Cerebellar Motor Syndromementioning

confidence: 99%