In this paper, we prove that, a compact complex manifold X admits a smooth Hermitian metric with positive (resp. negative) scalar curvature if and only if KX (resp. K −1 X ) is not pseudo-effective. On the contrary, we also show that on an arbitrary compact complex manifold X with complex dimension ≥ 2, there exist smooth Hermitian metrics with positive total scalar curvature, and one of the key ingredients in the proof relies on a recent solution to the Gauduchon conjecture by G. Székelyhidi, V. Tosatti and B. Weinkove([19, Theorem 1.3]).