Scalable inference of cell differentiation networks in gene therapy clonal tracking studies of haematopoiesis
Luca Del Core,
Danilo Pellin,
Ernst C Wit
et al.
Abstract:Motivation
Investigating cell differentiation under a genetic disorder offers the potential for improving current gene therapy strategies. Clonal tracking provides a basis for mathematical modelling of population stem cell dynamics that sustain the blood cell formation, a process known as haematopoiesis. However, many clonal tracking protocols rely on a subset of cell types for the characterisation of the stem cell output, and the data generated are subject to measurement errors and noise.
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