Scalable Condition-relevant Cell Niche Analysis of Spatial Omics Data with Taichi
Yan Cui,
Zhiyuan Yuan
Abstract:Tissues are composed of heterogeneous cell niches, which can be investigated using spatial omics technologies. Large consortia have accumulated vast amounts of spatially resolved data, which typically assign slice-level condition labels without considering intra-slice heterogeneity, particularly differential cell niches that respond to certain perturbations. Here, we present Taichi, an efficient and scalable method for condition-relevant cell niche analysis that does not rely on pre-defined discrete spatial cl… Show more
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