“…The most significant colocalization occurred between a variant for sleeping disorders and an editing site in the first non-coding exon of C16orf72 , previously linked to cognition, learning, and sleeping difficulties. 74 , 75 This editing site occurs in a non-coding regulatory region that has been shown to modulate mRNA stability and protein abundance. 76 To further dissect such mechanisms and their implications for brain maturation and disease risk, it will be critical for future work to greatly increase sample sizes.…”