Abstract:We show that the behavior of a polymorphic transformation under high shear can be predicted up to pilot scales on the basis of laboratory experiments. Solubility measurements indicate that the transformation rate is promoted at higher temperatures and that within the studied temperature range, the thermodynamically preferred form exhibits retrograde solubility. High shear, introduced both by a rotor-stator combination and by the use of high-surface area seeds, promotes the transformation, resulting in shorter … Show more
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