Scaffolds with tuneable hydrophilicity from electrospun microfibers of polylactide and poly(ethylene glycol) mixtures: morphology, drug release behavior, and biocompatibility

Llorens, Elena; Valle, Luís J. del; Ferrán, Ricard; Rodríguez‐Galán, Alfonso; Puiggalı́, Jordi

doi:10.1007/s10965-014-0360-4

Cited by 22 publications

(17 citation statements)

References 38 publications

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“…Texture of microfibers was slightly different depending on the loaded drugs as shown in the high‐magnification SEM micrographs of Figure . In general, microfibers had a porous structure as it is also commonly observed for unloaded PLA electrospun fibers . The presence of longitudinal striations was also usual in most of the prepared samples (Figure , see red arrows).…”

Section: Resultssupporting

confidence: 62%

“…Note, for example, the large difference between reported Hildebrand parameters for PLA [i.e., 9.87 (cal/cm 3 ) 0.5 ] and TCS [i.e., 14.38 (cal/cm 3 ) 0.5 ]. In addition, a relatively high polymer concentration is required to avoid formation of drops or beads and obtain continuous fibers in a micrometer scale, which appears more appropriate for a sustained drug release. These factors focused us to select a chloroform:acetone:dimethylsulfoxide mixture with a 6:3:1 v / v / v ratio; specifically, the two first solvents were appropriate to obtain PLA electrospun microfibers, whereas the third solvent was essential to allow dissolution of the three selected drugs (TCS, CUM, and KTP).…”

Section: Resultsmentioning

confidence: 99%

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Multifunctional ternary drug‐loaded electrospun scaffolds

Llorens

Valle

Puiggalı́

2015

J of Applied Polymer Sci

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Multifunctional electrospun scaffolds were prepared from two PLA grades having slightly different D-lactide content (4.2 wt-% and 2.0 wt-%). Triclosan (TCS), ketoprofen (KTP) and p-coumaric acid (CUM) were selected as bactericide, antiinflammatory and antioxidant agents, respectively. Single, binary and ternary drugloaded microfibers having a unimodal diameter distribution could be prepared using a common chloroform:acetone:dimethylsulfoxide mixture and similar operational parameters (i.e. voltage, flow rate and tip-collector distance). FTIR spectra were sensitive to the low amount of drugs loaded and even showed slight differences in PLA conformation. DSC heating scans clearly demonstrated the ability of electrospinning to induce molecular orientation of PLA and also the nucleation effect of incorporated drugs to induce crystallization. Thus, crystallinity of binary drug-loaded scaffolds was significantly higher than observed for unloaded samples.Release behavior of the three drugs from loaded scaffolds and PLA matrices in PBS:ethanol medium was evaluated. A rapid release was always detected, together with partial drug retention which was higher when the more stereoregular PLA matrix was employed. A strong bactericide effect was found when scaffolds were loaded with 3 w/v-% of TCS, but incorporation of a small percentage of KTP (i.e. 1 w/v-%) had a bacteriostatic effect even in the absence of TCS. The inherent cytotoxicity of TCS could be well neutralized by enhancing cell viability by incorporation of CUM and/or KTP.3

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Section: Resultssupporting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Multifunctional ternary drug‐loaded electrospun scaffolds

Llorens

Valle

Puiggalı́

2015

J of Applied Polymer Sci

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“…PBSeT-70 was expected to be more favourable for cell colonization as has been reported for other systems [30]. The increase of hydrophilicity could also influence the degradability of the sample but as it will then be discussed, the main and most decisive influencing factor could be attributed to the greater susceptibility of the aliphatic ester bonds to hydrolysis.…”

Section: Biocompatibility Of Pbset-x Copolymersmentioning

confidence: 75%

Biodegradability and biocompatibility of copoly(butylene sebacate-co-terephthalate)s

Heidarzadeh

Rafizadeh

Taromi

et al. 2017

Polymer Degradation and Stability

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In the present study poly (butylene sebacate-co-terephthalate)s having different compositions were synthesized with a high yield and a random distribution by thermal transesterification of poly (butylene sebacate) and poly (butylene terephthalate) homopolymers. The copolymer with the highest comonomer ratio was the least crystalline sample, although the melting peaks corresponding to both, sebacate and terephthalate-rich phases were still observable in calorimetric heating runs. This copolymer was associated with interesting thermal and mechanical properties, as the maximum melting point was higher than 100 °C and the storage modulus was also high (i.e. 1.1 × 109 N/m2 and 1.7 108 N/m2 were determined just before and after the main glass transition temperature of -12 °C).\ud \ud As all studied samples were thermally stable up to temperatures clearly higher than the fusion temperature, they could be easily processed. Increasing the terephthalate content of the copolymers resulted in higher hydrophobicity, which had a minor influence on cell adhesion and proliferation of both fibroblast-like and epithelial-like cells. Hydrolytic and enzymatic degradability were assessed and the effect of composition and crystallinity on the degradation rate was investigated. Molecular weight measurements during exposure to a hydrolytic media indicated a first order kinetic mechanism during the initial stages of degradation before reaching a limiting molecular size, which was indicative of solubilization. The most amorphous sample appears as a highly promising biodegradable material since it showed a significant weight loss during exposure to all selected degradation media, but also exhibited good performance and properties that were comparable to those characteristic of polyethylenePeer ReviewedPostprint (author's final draft

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“…They are widely employed for many applications such as sutures, materials for tissue regeneration, orthopedics, scaffolds and systems for controlled release of drugs in medicine [7][8][9][10][11][12]. The great interest in PLA based bionanocomposites is directly supported by the significant increase in the number of derived scientific publications [13], which clearly demonstrates an improvement of biodegradation rate and mechanical, thermomechanical and gas barrier properties [14,15].…”

Section: Introductionmentioning

confidence: 99%

Preparation of micro-molded exfoliated clay nanocomposites by means of ultrasonic technology

et al. 2014

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Ultrasound micro-molding technology has been tested as a new method to get polymer/clay nanocomposites. Biodegradable polylactide (PLA) and poly (nona-methylene azelate) (PE99) have been used as polymer matrices, whereas different silicate clays have been assayed. The new technology is able to get specimens without evidences of degradation during processing. Only the use of organo-modified clays could give rise to a slight molecular weight decrease when the poly (alkylene dicarboxylate) sample was considered. Ultrasonic micro-molding has revealed effective to get directly nanocomposites with the final form required for a selected application, a homogeneous clay distribution up to a load of 6 wt-% and more interestingly exfoliated structures without being necessary the use of a compatibilizer agent between the organic polymer and the inorganic silicate clay. Transmission electron micrographs and X-ray diffraction profiles revealed exfoliated structure when N757, C20A, C25A, and N848 clays were employed.; Crystallization behavior of exfoliated PLA nanocomposites was highly peculiar since clay particles had an antinucleating effect that decreased the overall crystallization rate respect to the neat polymer. In addition, the incorporation of layers into growing spherulites increased the crystal growth rate. A typical crystallization effect was on the contrary observed for nanocomposites derived from the poly (alkylene dicarboxylate) sample.Peer ReviewedPostprint (published version

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Scaffolds with tuneable hydrophilicity from electrospun microfibers of polylactide and poly(ethylene glycol) mixtures: morphology, drug release behavior, and biocompatibility

Cited by 22 publications

References 38 publications

Multifunctional ternary drug‐loaded electrospun scaffolds

Multifunctional ternary drug‐loaded electrospun scaffolds

Biodegradability and biocompatibility of copoly(butylene sebacate-co-terephthalate)s

Preparation of micro-molded exfoliated clay nanocomposites by means of ultrasonic technology

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