Scaffolds for parathyroid tissue engineering

Jo, Inho; Park, Yoon Shin; Oh, Se Young; Jung, Sung Chul; Kim, Hansu; Lee, Yunki; Hwang, Ji Young; Парк, Ки Донг

doi:10.1016/b978-0-08-102561-1.00033-6

Cited by 1 publication

(1 citation statement)

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“…As for transplantation, allotransplantation was first used in postsurgical hypoparathyroidism but is still not popular enough considering the shortage of safe and functional cell or tissue resources (Agha et al, 2016; Khryshchanovich & Ghoussein, 2016; Tibell et al, 2001). Moreover, Jo et al summarized several attempts combined biomaterial scaffolds and rhPTH alone excepting cells for transplanting to cure hypoparathyroidism, and the lack of feedback regulation means it is not an ideal way for long‐term effect (Jo et al, 2019).…”

Section: Parathyroid‐related Diseases and Clinical Therapiesmentioning

confidence: 99%

Tissue‐engineered parathyroid gland and its regulatory secretion of parathyroid hormone

Guo

Liang

et al. 2020

J Tissue Eng Regen Med

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Parathyroid glands (PTGs) are important endocrine organs being mainly responsible for the secretion of parathyroid hormone (PTH) to regulate the balance of calcium (Ca) /phosphorus (P) ions in the body. Once PTGs get injured or removed, their resulting defect or loss of PTH secretion should disturb the level of Ca/P in blood, thus damaging other related organs (bone, kidney, etc.) and even causing death. Recently, tissue-engineered PTGs (TE-PTGs) have attracted lots of attention as a potential treatment for the related diseases of PTGs caused by hypoparathyroidism and hyperparathyroidism, including tetany, muscle cramp, nephrolithiasis, nephrocalcinosis, and osteoporosis. Although great progress has been made in the establishment of TE-PTGs with an effective strategy to integrate the key factors of cells and biomaterials, its regulatory secretion of PTH to mimic its natural rhythms in the body remains a huge challenge. This review comprehensively describes an overview of PTGs from physiology and pathology to cytobiology and tissue engineering. The state of the arts in TE-PTGs and the feasible strategies to regulate PTH secretion behaviors are highlighted to provide an important foundation for further investigation.

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