Scaffolds for esophageal tissue engineering

Jones, E; Jensen, Todd; Sharma, Ishna; Wanczyk, Heather; Mitchell, A. B.; Foster, C. M.; Sayej, Wael N.; Finck, Christine

doi:10.1016/b978-0-08-102561-1.00023-3

Cited by 3 publications

(4 citation statements)

References 97 publications

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“…25 cm), small intestine = convoluted tube with D = [2.5-4] cm, L = [2-4] m, large intestine: D = approx. 7 cm, L = 1.5 m [Egorov et al, 2002;Marieb and Hoehn, 2010;Bitar et al, 2014;Luc et al, 2014;Maghsoudlou et al, 2014;Fedoruk and Hong, 2014;Londono and Badylak, 2015;Jensen et al, 2015;Poghosyan et al, 2016;Arakelian et al, 2018;Urbanska et al, 2018;Noh, 2018;Dosh et al, 2018;Hussey et al, 2018;Kanetaka et al, 2018;Kanetkar and Ekenseair, 2019;Kovler and Hackam, 2019;Jones et al, 2019;Qi et al, 2020] MR: [Lomholt, 1992;Habib et al, 1994;Gregersen and Kassab, 1996;Rao et al, 1996;…”

Section: Processing Techniques For the Development Of Tubular Constru...mentioning

confidence: 99%

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

Pien

Palladino

Copes

et al. 2021

Cells Tissues Organs

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In this featured review manuscript, the aim is to present a critical survey on the processes available for fabricating bioartificial organs (BAOs). The focus will be on hollow tubular organs for the transport of anabolites and catabolites, i.e., vessels, trachea, esophagus, ureter and urethra, and intestine. First, the anatomic hierarchical structures of tubular organs, as well as their principal physiological functions, will be presented, as this constitutes the mandatory requirements for effectively designing and developing physiologically relevant BAOs. Second, 3D bioprinting, solution electrospinning, and melt electrowriting will be introduced, together with their capacity to match the requirements imposed by designing scaffolds compatible with the anatomical and physiologically relevant environment. Finally, the intrinsic correlation between processes, materials, and cells will be critically discussed, and directives defining the strengths, weaknesses, and opportunities offered by each process will be proposed for assisting bioengineers in the selection of the appropriate process for the target BAO and its specific required functions.

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Section: Processing Techniques For the Development Of Tubular Constru...mentioning

confidence: 99%

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

Pien

Palladino

Copes

et al. 2021

Cells Tissues Organs

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show abstract

“…ANOVA performed for average surface roughness, radial compressive load and percentage of elongation are shown in Tables 4 to 6. The regression models after eliminating insignificant terms for output responses are shown by equations ( 4)- (6).…”

Section: Statistical Modelling Of Output Responsesmentioning

confidence: 99%

“…It has emerged as one of the alternative approaches in the field of tissue and organ regeneration. In last few years, considerable work has been done in the field of tissue engineering of vascular grafts, 4 tracheal scaffolds, 5 oesophagal scaffolds 6 and ureter scaffolds 7 aiming to generate biomimetic supports without sacrificing the long term patency and growth potential. Thomas et al 8 attempted to fabricate biomimetic aterial scaffold of internal diameter 4 mm with three different layers namely polydioxanone (PDS) and protein layers of fibrin and gelatin.…”

Section: Introductionmentioning

confidence: 99%

Statistical modelling and optimization of print quality and mechanical properties of customized tubular scaffolds fabricated using solvent-based extrusion 3D printing process

Kandi

Pandey

2021

Proc Inst Mech Eng H

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Tissue-engineered tubular scaffolds offer huge potential to heal or replace the diseased organ parts like blood vessels, trachea, oesophagus and ureter. However, manufacturing these scaffolds in various scales and shapes is always challenging and requires progressive technology. Developing a flexible and accurate manufacturing method is a major developmental direction in the field of tubular scaffold fabrication. In this context, the present work presents a novel solvent-based extrusion 3D printing which allows extruding over a rotating mandrel to fabricate tubular scaffolds of polycaprolactone (PCL) and polyurethane (PU). Experimental runs were planned as per the central composite design (CCD) to evaluate the effects of input parameters like infill density, layer thickness, print speed and percentage of PU on the output responses like printing quality and mechanical characteristics. The printing quality was quantified by measuring average surface roughness of the printed scaffolds and mechanical properties were evaluated by measuring radial compressive load, and percentage of elongation. The experimental investigations revealed that printing quality was improved at higher infill densities and was deteriorated at higher print speeds and layer thicknesses. Similarly, the radial compressive load was improved with the increase in infill density and was decreased with an increase in layer thickness, print speed and percentage of PU. The percentage of elongation was found to improve at higher infill densities and percentages of PU and was reduced with an increase in layer thickness and print speed. Additionally, a multi-objective optimization using Genetic Algorithm was used to evaluate the optimum conditions to minimize surface roughness and maximizing radial compression load and percentage of elongation. Finally, a case study was performed by comparing the mechanical properties of tubular organs and scaffolds from the existing reports and results of the present work.

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“…Polyesters and polyurethanes have also been investigated as replacement materials for the small intestinal submucosa, the esophageal submucosa, the gastric acellular matrix, or the aortic acellular matrix 34 . Current synthetic devices are now shifting from prosthetics towards scaffold materials to favor regeneration of tissues and long-term biocompatibility, by using biodegradable polymers such as: poly-lactic acid (PLA), polyglycolic acid (PGA), poly-l-lactic acid (PLLA), their copolymer poly(lactide-co-glycolide) and polycaprolactone (PCL) 35 . Another alternative route is to take benefit of the mechanical properties of synthetic polymers, and combine them to biologically derived components to enhance their biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic materials to replace tubular tissues

Martinier,

Trichet,

Fernandes

2024

Preprint

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Repairing tubular tissues—the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system—from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials. Despite their apparent diversity, tubular tissues share extensive compositional and structural features. Here, we assess the current state of the art through a dual layer model, reducing each tissue to an inner epithelial layer and an outer muscular layer. Based on this model, we examine the current strategies developed to mimic each layer and we underline how each fabrication method stands in providing a biomimetic material for future clinical translation. The analysis provided here, addressed to materials chemists, biomaterials engineers and clinical staff alike, sets new guidelines to foster the elaboration of new biomimetic materials for effective tubular tissue repair.

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Scaffolds for esophageal tissue engineering

Cited by 3 publications

References 97 publications

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

Statistical modelling and optimization of print quality and mechanical properties of customized tubular scaffolds fabricated using solvent-based extrusion 3D printing process

Biomimetic materials to replace tubular tissues

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