Scaffold Designing

Izquierdo‐Barba, Isabel

doi:10.1002/9781118406748.ch10

Cited by 9 publications

(3 citation statements)

References 89 publications

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“…There are different strategies aimed to prepare bioactive glass‐based scaffolds . Among them, foaming and electrospinning methods are some of the most important strategies used so far.…”

Section: Macro‐architectural Design Of Bioactive Glassesmentioning

confidence: 99%

“…There are different strategies aimed to prepare bioactive glass-based scaffolds. [44][45][46][47] Among them, foaming 48 and electrospinning 49 methods are some of the most important strategies used so far. The preparation of bioactive glass macroporous scaffolds through foaming processes has been widely studied and optimized.…”

Section: Macro-architectural Design Of Bioactive Glassesmentioning

confidence: 99%

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Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds

Vallet‐Regí

Salinas

Arcos

2016

Int J of Appl Glass Sci

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Abstract:Bioactive glasses are going to play an essential role in the manufacture of 3D scaffolds for bone tissue engineering. Mimicking natural bone, synthetic scaffolds must be tailored at a hierarchy of scales. First, the glasses composition must be carefully designed at the atomic-molecular level to ensure bioactivity and beneficial effects including capabilities for enhance osteogenesis and vascularization or to exert bactericide action. Moreover, the glasses structure need to be designed at the nanometric scale. With this purpose, mesoporous bioactive glasses, exhibiting ordered arrangements of nanometric pores, are optimum candidates. The microstructure of glasses must also be designed to achieve suitable interactions with living cells. Finally, the scaffolds obtained with bioactive glasses must display interconnected pores over 100 µm to made possible bone cell ingrowths and angiogenesis. In this article, the advances in the field of bioactive glasses through the control of the chemical, nanometer scale, microstructural properties and architectural features are presented and discussed. A detailed control of these four levels of matter organization will allow optimizing the biological response of bioactive glasses when used in bone tissue regeneration. AbstractBioactive glasses are going to play an essential role in the manufacture of 3D scaffolds for bone tissue engineering. Mimicking natural bone, synthetic scaffolds must be tailored at a hierarchy of scales. First, the glasses composition must be carefully designed at the atomic-molecular level to ensure bioactivity and beneficial effects including capabilities for enhance osteogenesis and vascularization or to exert bactericide action. Moreover, the glasses structure need to be designed at the nanometric scale. With this purpose, mesoporous bioactive glasses, exhibiting ordered arrangements of nanometric pores, are optimum candidates. The microstructure of glasses must also be designed to achieve suitable interactions with living cells. Finally, the scaffolds obtained with bioactive glasses must display interconnected pores over 100 µm to made possible bone cell ingrowths and angiogenesis. In this article, the advances in the field of bioactive glasses through the control of the chemical, nanometer scale, microstructural properties and architectural features are presented and discussed.A detailed control of these four levels of matter organization will allow optimizing the biological response of bioactive glasses when used in bone tissue regeneration.

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“…There are different strategies aimed to prepare bioactive glass‐based scaffolds . Among them, foaming and electrospinning methods are some of the most important strategies used so far.…”

Section: Macro‐architectural Design Of Bioactive Glassesmentioning

confidence: 99%

Section: Macro-architectural Design Of Bioactive Glassesmentioning

confidence: 99%

Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds

Vallet‐Regí

Salinas

Arcos

2016

Int J of Appl Glass Sci

View full text Add to dashboard Cite

show abstract

“…Moreover, this technique was demonstrated to be effective in the fabrication of multi-layered scaffolds, which also exhibit widespread applications in biomimetic TE, i.e., scaffolds with a nano-scaled architecture. However, this technique presents the disadvantage of being significantly energy-and time-consuming, and the resulted pore sizes are substantially smaller than would be expected for supporting penetration and differentiation of certain types of cells [47,51,52]. According to the authors, this result is related to the porous structure of freeze-dried scaffolds showing larger pore size, higher porosity, and interconnection rather than the fibrous structure of the electrospun PLGA/HA constructs.…”

Section: Freeze-dryingmentioning

confidence: 99%

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

et al. 2021

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The fabrication of 3D scaffolds is under wide investigation in tissue engineering (TE) because of its incessant development of new advanced technologies and the improvement of traditional processes. Currently, scientific and clinical research focuses on scaffold characterization to restore the function of missing or damaged tissues. A key for suitable scaffold production is the guarantee of an interconnected porous structure that allows the cells to grow as in native tissue. The fabrication techniques should meet the appropriate requirements, including feasible reproducibility and time- and cost-effective assets. This is necessary for easy processability, which is associated with the large range of biomaterials supporting the use of fabrication technologies. This paper presents a review of scaffold fabrication methods starting from polymer solutions that provide highly porous structures under controlled process parameters. In this review, general information of solution-based technologies, including freeze-drying, thermally or diffusion induced phase separation (TIPS or DIPS), and electrospinning, are presented, along with an overview of their technological strategies and applications. Furthermore, the differences in the fabricated constructs in terms of pore size and distribution, porosity, morphology, and mechanical and biological properties, are clarified and critically reviewed. Then, the combination of these techniques for obtaining scaffolds is described, offering the advantages of mimicking the unique architecture of tissues and organs that are intrinsically difficult to design.

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How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

et al. 2021

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Despite progresses in tissue healing, repairing large bone defects remains an unmet challenge. Tissue engineering (TE) using porous scaffolds offers great promise in providing solutions by which bone healing can be increased, and the need for further surgical intervention can be reduced. Nonetheless, the successful performance of a porous scaffold depends on key structural factors including porosity, pore size, geometry, and interconnectivity. Herein, recent advancements on this topic are reviewed and the effects of fabrication methods on making potential scaffolds for advanced bone regeneration are discussed.The upward trend of population aging, increased numbers of accidents, sport injuries, trauma, and bone tumor resection are increasing the demand for substitutes to regenerate and/or repair damaged skeletal and dental bones. [1] Bone tissue poses a simple yet highly organized ultracomposition in which each portion plays a pivotal role in moderating the elasticity and strength of the bone. [2] The intrinsically dynamic bone tissue structure allows the restoration of damaged parts via the self-healing process. [3] This remodeling process is dependent on the dynamic equilibrium between the bone-forming (osteoblast) and bone-resorbing cells (osteoclast) during mechanical stimulation. [4] Nevertheless, this healing process is not sufficient for repairing massive and critical bone defects; thus, there is a need for drastic healing accelerators and substitutive or supportive therapeutics. [5] Specially, the regenerating of large bone defects is a serious and challenging clinical issue. To address the issue, different types of bone graft substitutes such as autografts, allografts, and xenografts are used. [6] These grafts, however, come with certain drawbacks, including donor site morbidity and limited supply. Moreover, aged persons cannot provide rich bone tissue for their own tissue replacement due to osteoporosis. [7] To address the limitations associated with natural bone-derived substitutes, biomaterials have been developed during recent decades. [8] Engineering biomaterials made it possible to simulate the bone microenvironment and construct programmable scaffolds for purposeful therapeutic procedures. Bioactive ceramic materials are favorable for bone tissue engineering (BTE) due to their resemblance to the mineral phase of bone, and direct bonding with host bone tissue without the formation of fibrous tissue. In addition, the variety in the chemical composition of bioceramics, particularly silicate-based ceramics (SiCa), can contribute to adjustments in mechanical properties, bioactivity, and biodegradability.A fundamental constituent of engineering tissue is the scaffold, which acts as the structural template providing a suitable substrate for cell proliferation, differentiation, and attachment resulting in new tissue formation. In tissue engineering (TE), the scaffold serves as the structural guide and the substrate for cell anchorage. The scaffold also contributes to the remodeling of the extracellular mat...

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Scaffold Designing

Cited by 9 publications

References 89 publications

Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds

Tailoring the Structure of Bioactive Glasses: From the Nanoscale to Macroporous Scaffolds

Solution-Based Processing for Scaffold Fabrication in Tissue Engineering Applications: A Brief Review

How Does Scaffold Porosity Conduct Bone Tissue Regeneration?

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