Scaffold Design for Tissue Engineering

Using Plasma Deposits to Promote Cell Population of the Porous Interior of Three-Dimensional Poly(D,L-Lactic Acid) Tissue-Engineering Scaffolds

“…The O 1s core-level spectrum ( Fig. 1E) indicates that the treatment has reduced the concentration of the C±OX environment at the surface of the P DL LA in comparison to the OC environment, where X = H or R (where R is a functional group such as CH 3 ), probably as a result of a combination of the rupture of the ester linkage and subsequent formation of aldehyde groups during the plasma treatment. This is consistent with the increase in width and binding energy of the C 1s component, originally positioned at a shift of 2.1 eV (Fig.…”

“…[1,2] The key premise in tissue-engineering strategies, however, is the use of this and other biodegradable polymers to make three-dimensional (3D) scaffold structures that are porous throughout their volume, allowing ingress and adhesion of regenerating tissue. [3,4] For this application, it is important that high numbers of viable cells populate the entirety of the scaffold, synthesizing and depositing extracellular matrix proteins. Reduced attachment on these surfaces will therefore affect the efficiency of scaffold-seeding strategies and the production of tissue, such that tissue formation may only occur at the outer edges.…”

Happy Birthday, MBS!

“…Steinbüchel [11] Scaffold Design for Tissue Engineering G. P. Chen et al [12] Chemical Modification of Chitosan, 17 -Michael Reaction of Chitosan with Acrylic Acid in Water H. Sashiwa et al [13] An Overview of Polylactides as Packaging Materials R. Auras et al [14] Ionic Liquids as Reaction Medium in Cellulose Functionalization T. Heinze et al [15] Alginate Hydrogels as Biomaterials A. D. Augst et al [16] Designer Self-Assembling Peptide Materials S. G. Zhang et al [17] Preparation of Biodegradable Polymer Nanoparticles by Miniemulsion Technique and Their Cell Interactions K. Landfester et al [18] Thermo-Responsive Polyoxazolines with Widely Tuneable LCST H. Schlaad et al [19] forward to entering with you the next decade of success!…”

“…Xuesi Chen (Changchun Institute of Applied Chemistry) guest-edited the second special issue which was devoted to ''Biomaterials in China'' (issue 12,2009). Although great progress has been achieved in the interdisciplinary field of macromolecular bioscience in China in recent years, the influence exerted by Chinese scientists working in this area on a global scale is still limited.…”

Surface Functionalization of Porous Resorbable Scaffolds by Covalent Grafting

“…The commonly used biomaterials poly(L-lactide) and poly(e-caprolactone) have been widely used for scaffold purposes but other alternatives have also been presented, such as injectible poly(propylene fumarate), or aliphatic ester copolymers with well-defined architectures and compositions designed with ring-opening polymerization. [2][3][4][5] However, the polymers used in scaffolds are typically way too hydrophobic to provide good conditions for wetting of the medium, cell attachment, and cell growth. [6] Also, their surfaces inherently lack the functional and bioactive groups that mediate enhanced and controlled biological performance.…”