Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Fu, Jiang-Nan; Wang, Xing; Yang, Meng; Chen, You‐Rong; Zhang, Jiying; Deng, Rong‐Hui; Zhang, Zining; Yu, Jia‐Kuo; Yuan, Fu‐Zhen

doi:10.3389/fbioe.2021.812383

Cited by 36 publications

(22 citation statements)

References 204 publications

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“…Additionally, many authors highlight the efficiency of metallic, biological, and composite scaffolds for BTE [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. A list of scaffold fabrication techniques includes lyophilization, freeze and solvent casting, gas and microfluidic foaming, melt and compression molding, particulate leaching, phase separation process, and electrospinning [ 62 , 63 , 64 ]. Significant progress in manufacturing scaffolds has emerged due to the development and implementation of 3D printing technology [ 65 , 66 ].…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

“…Significant progress in manufacturing scaffolds has emerged due to the development and implementation of 3D printing technology [ 65 , 66 ]. Additive manufacturing approaches are classified in to extrusion-based, powder-based, and photopolymerization techniques [ 62 , 67 , 68 , 69 ]. The main types of the scaffolds for BTE, their crucial properties, fabrication and sterilization techniques are summarized in Table 1 .…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

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In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical translation of BTE requires overcoming a number of significant challenges. Currently, insufficient vascularization is the critical limitation for viability of the bone tissue-engineered construct. Furthermore, efficacy and safety of the scaffolds cell-seeding and exogenous growth factors administration are still controversial. The in vivo bioreactor principle (IVB) is an exceptionally promising concept for the in vivo bone tissue regeneration in a predictable patient-specific manner. This concept is based on the self-regenerative capacity of the human body, and combines flap prefabrication and axial vascularization strategies. Multiple experimental studies on in vivo BTE strategies presented in this review demonstrate the efficacy of this approach. Routine clinical application of the in vivo bioreactor principle is the future direction of BTE; however, it requires further investigation for to overcome some significant limitations.

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Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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“…The basic element of tissue engineering relies on cells, scaffolds, and growth factors. Traditional strategies in tissue engineering always incorporate the use of stem cells to regenerate new tissue in damaged areas [ 4 , 5 , 6 , 7 , 8 ]. In this case, various scaffolds provide attachment sites for cells and a protective environment for the proliferation and differentiation of attached cells.…”

Section: Introductionmentioning

confidence: 99%

Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

Chang

Wang

Liu

et al. 2022

Gels

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Bone defects, as one of the most urgent problems in the orthopedic clinic, have attracted much attention from the biomedical community and society. Hydrogels have been widely used in the biomedical field for tissue engineering research because of their excellent hydrophilicity, biocompatibility, and degradability. Stimulus-responsive hydrogels, as a new type of smart biomaterial, have more advantages in sensing external physical (light, temperature, pressure, electric field, magnetic field, etc.), chemical (pH, redox reaction, ions, etc.), biochemical (glucose, enzymes, etc.) and other different stimuli. They can respond to stimuli such as the characteristics of the 3D shape and solid–liquid phase state, and exhibit special properties (injection ability, self-repair, shape memory, etc.), thus becoming an ideal material to provide cell adhesion, proliferation, and differentiation, and achieve precise bone defect repair. This review is focused on the classification, design concepts, and research progress of stimulus-responsive hydrogels based on different types of external environmental stimuli, aiming at introducing new ideas and methods for repairing complex bone defects.

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“…Osteochondral injuries due to trauma, sports injuries, or pathological factors, which involve both articular cartilage and subchondral bone tissue, are notorious for being incurable and for seriously affecting the normal activities of human joints, thereby causing not only a huge economic and psychological burden to patients but also consuming a large amount of public medical resources − Therefore, the search for an effective osteochondral repair strategy is a pressing clinical and scientific problem. Traditional bone tissue engineering involves directly transforming the mesenchymal stem cells (MSCs) into osteoblasts to form bone matrix through intramembranous ossification (IMO).…”

Section: Introductionmentioning

confidence: 99%

Functionalized Microscaffold–Hydrogel Composites Accelerating Osteochondral Repair through Endochondral Ossification

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Osteochondral regeneration remains a key challenge because of the limited self-healing ability of the bone and its complex structure and composition. Biomaterials based on endochondral ossification (ECO) are considered an attractive candidate to promote bone repair because they can effectively address the difficulties in establishing vascularization and poor bone regeneration via intramembranous ossification (IMO). However, its clinical application is limited by the complex cellular behavior of ECO and the long time required for induction of the cell cycle. Herein, functionalized microscaffold–hydrogel composites are developed to accelerate the developmental bone growth process via recapitulating ECO. The design comprises arginine–glycine–aspartic acid (RGD)-peptide-modified microscaffolds loaded with kartogenin (KGN) and wrapped with a layer of RGD- and QK-peptide-comodified alginate hydrogel. These microscaffolds enhance the proliferation and aggregation behavior of the human bone marrow mesenchymal stem cells (hBMSCs); the controlled release of kartogenin induces the differentiation of hBMSCs into chondrocytes; and the hydrogel grafted with RGD and QK peptide facilitates chondrocyte hypertrophy, which creates a vascularized niche for osteogenesis and finally accelerates osteochondral repair in vivo. The findings provide an efficient bioengineering approach by sequentially modulating cellular ECO behavior for osteochondral defect repair.

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Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Cited by 36 publications

References 204 publications

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

Advances of Stimulus-Responsive Hydrogels for Bone Defects Repair in Tissue Engineering

Functionalized Microscaffold–Hydrogel Composites Accelerating Osteochondral Repair through Endochondral Ossification

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