Scaffold-based tissue engineering approaches in treating infertility

Jahanbani, Yalda; Davaran, Soudabe; Ghahremani-Nasab, Maryam; Aghebati‐Maleki, Leili; Yousefi, Mehdi

doi:10.1016/j.lfs.2019.117066

Cited by 32 publications

(13 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to the majority of treatments, cell therapy could be accompanied by side effects, particularly in stem cell therapy [ 76 ]. For instance, prior to using stem cells, they should be grown for several months after they are harvested from embryos.…”

Section: Stem Cells Therapymentioning

confidence: 99%

Cell-based therapy in thin endometrium and Asherman syndrome

et al. 2022

Self Cite

View full text Add to dashboard Cite

Numerous treatment strategies have so far been proposed for treating refractory thin endometrium either without or with the Asherman syndrome. Inconsistency in the improvement of endometrial thickness is a common limitation of such therapies including tamoxifen citrate as an ovulation induction agent, acupuncture, long-term pentoxifylline and tocopherol or tocopherol only, low-dose human chorionic gonadotropin during endometrial preparation, aspirin, luteal gonadotropin-releasing hormone agonist supplementation, and extended estrogen therapy. Recently, cell therapy has been proposed as an ideal alternative for endometrium regeneration, including the employment of stem cells, platelet-rich plasma, and growth factors as therapeutic agents. The mechanisms of action of cell therapy include the cytokine induction, growth factor production, natural killer cell activity reduction, Th17 and Th1 decrease, and Treg cell and Th2 increase. Since cell therapy is personalized, dynamic, interactive, and specific and could be an effective strategy. Despite its promising nature, further research is required for improving the procedure and the safety of this strategy. These methods and their results are discussed in this article.

show abstract

Section: Stem Cells Therapymentioning

confidence: 99%

Cell-based therapy in thin endometrium and Asherman syndrome

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Notably, the use of scaffolds in cell transplantation helps cell attachment, growth, and proliferation. Such structures can reduce cell necrosis and apoptosis in the first days following cell transplantation (Gao, 2016;Ghahremani-Nasab et al, 2019;Gunatillake & Adhikari, 2003;Jahanbani et al, 2020). Overall, there are many challenges for using such therapeutic methods, though clinical reports will continue to evolve and general trends will emerge.…”

Section: Cell-based Therapiesmentioning

confidence: 99%

Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases

Jahanbani

Shafiee

Davaran

et al. 2021

Cell Biology International

Self Cite

View full text Add to dashboard Cite

In recent years, stem cells have known as a helpful biological tool for the accurate diagnosis, treatment and recognition of diseases. Using stem cells as biomarkers have presented high potential in the early detection of many diseases. Another advancement in stem cell technology includes stem cell derived organoids model that could be a promising platform for diagnosis and modeling different diseases.Furthermore, therapeutic capabilities of stem cell therapy have increased hope in the face of different disability managements. All of these technologies are also widely used in reproductive related diseases especially in today's world that many couples encounter infertility problems. However, with the aid of numerous improvements in the treatment of infertility, over 80% of couples who dreamed of having children could now have children. Due to the fact that infertility has many negative effects on personal and social lives of young couples, many researchers have focused on the treatment of male and female reproductive system abnormalities with different types of stem cells, including embryonic stem cells, bone marrow mesenchymal stem cells (MSCs), and umbilical cord-derived MSCs. Also, design and formation of reproductive system organoids provide a fascinating window into disease modeling, drug screening, personalized therapy, and regeneration medicine. Utilizing these techniques to study, model and treat the infertility-related diseases has drawn attention of many scientists. This review explains different applications of stem cells in generating reproductive system organoids and stem cell-based therapies for male and female infertility related diseases treatment.

show abstract

“…One strategy to mitigate this tissue growth is the placement of a biomaterial barrier within the uterus, such as an IUD. [ 310–312 ] To improve local coverage, a compressible porous scaffold was developed by Cai, et al. and studied in an intrauterine adhesion rat model.…”

Section: Tissue‐specific Applications Of Porous Biomaterialsmentioning

confidence: 99%

“…One strategy to mitigate this tissue growth is the placement of a biomaterial barrier within the uterus, such as an IUD. [310][311][312] To improve local coverage, a compressible porous scaffold was developed by Cai, et al and studied in an intrauterine adhesion rat model. Scaffolds enabled the delivery of basic fibroblast growth factor (bFGF), which together led to statistically equivalent endometrium and gland growth as undamaged uterine tissue, and greater neovascularization.…”

Section: Porous Materials In the Female Reproductive Tractmentioning

confidence: 99%

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Hernandez

Woodrow

2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Porosity is an important material feature commonly employed in implants and tissue scaffolds. The presence of material voids permits the infiltration of cells, mechanical compliance, and outward diffusion of pharmaceutical agents. Various studies have confirmed that porosity indeed promotes favorable tissue responses, including minimal fibrous encapsulation during the foreign body reaction (FBR). However, increased biofilm formation and calcification is also described to arise due to biomaterial porosity. Additionally, the relevance of host responses like the FBR, infection, calcification, and thrombosis are dependent on tissue location and specific tissue microenvironment. In this review, the features of porous materials and the implications of porosity in the context of medical devices is discussed. Common methods to create porous materials are also discussed, as well as the parameters that are used to tune pore features. Responses toward porous biomaterials are also reviewed, including the various stages of the FBR, hemocompatibility, biofilm formation, and calcification. Finally, these host responses are considered in tissue specific locations including the subcutis, bone, cardiovascular system, brain, eye, and female reproductive tract. The effects of porosity across the various tissues of the body is highlighted and the need to consider the tissue context when engineering biomaterials is emphasized.

show abstract

Scaffold-based tissue engineering approaches in treating infertility

Cited by 32 publications

References 83 publications

Cell-based therapy in thin endometrium and Asherman syndrome

Cell-based therapy in thin endometrium and Asherman syndrome

Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases

Medical Applications of Porous Biomaterials: Features of Porosity and Tissue‐Specific Implications for Biocompatibility

Contact Info

Product

Resources

About