Abstract::
Iron overload disorder and diseases where iron mismanagement plays a crucial role require
orally available iron chelators with favourable pharmacokinetic and toxicity profile. Desferrithiocin
(DFT), a tridentate and orally available iron chelator has a favourable pharmacokinetic profile but its
use has been clinically restricted due to its nephrotoxic potential. The chemical architecture of the DFT
has been naturally well optimized for better iron chelation and iron clearance from human biological
system. Eq… Show more
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