Scaffold-assisted cartilage tissue engineering using infant chondrocytes from human hip cartilage

Kreuz, Peter; Gentili, Chiara; Samans, Björn; Martinelli, Daniela; Krüger, Jan Philipp; Mittelmeier, Wolfram; Endres, Michaela; Cancedda, Ranieri; Kaps, Christian

doi:10.1016/j.joca.2013.09.007

Cited by 30 publications

(23 citation statements)

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“…Autologous chondrocytes are isolated and expanded before injection into the joint. Cultured chondrocyte transplantation has provided some good outcomes (Frisbie et al, 2008;Kreuz et al, 2013;Lee et al, 2003). However, this method also has some limitations, especially the lack of cultured chondrocyte sources, as almost all cultured chondrocytes die after long-term culture because of maturation.…”

Section: Introductionmentioning

confidence: 99%

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

et al. 2014

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Osteoarthritis is one of the most common diseases, and it affects 12% of the population around the world. Although the disease is chronic, it significantly reduces the patient’s quality of life. At present, stem cell therapy is considered to be an efficient approach for treating this condition. Mesenchymal stem cells (MSCs) show the most potential for stem cell therapy of osteoarthritis. In fact, MSCs can differentiate into certain mesodermal tissues such as cartilage and bone. Therefore, in the present study, we applied adipose tissue-derived MSCs to osteoarthritis treatment. This study aimed to evaluate the clinical efficiency of autologous adipose tissue-derived MSC transplantation in patients with confirmed osteoarthritis at grade II and III. Adipose tissue was isolated from the belly, and used for extraction of the stromal vascular fraction (SVF). The SVF was mixed with activated platelet-rich plasma before injection. The clinical efficiencies were evaluated by the pain score (VAS), Lysholm score, and MRI findings. We performed the procedure in 21 cases from 2012 to 2013. All 21 patients showed improved joint function after 8.5 months. The pain score decreased from 7.6±0.5 before injection to 3.5±0.7 at 3 months and 1.5±0.5 at 6 months after injection. The Lysholm score increased from 61±11 before injection to 82±8.1 after injection. Significant improvements were noted in MRI findings, with increased thickness of the cartilage layer. Moreover, there were no side-effects or complications related to microorganism infection, graft rejection, or tumorigenesis. These results provide a new opportunity for osteoarthritis treatment. Level of evidence: IV.

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Section: Introductionmentioning

confidence: 99%

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

et al. 2014

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show abstract

Section: Introductionmentioning

confidence: 99%

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

et al. 2014

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Abstract-Osteoarthritis is one of the most common diseases, and it affects 12% of the population around the world. Although the disease is chronic, it significantly reduces the patient's quality of life. At present, stem cell therapy is considered to be an efficient approach for treating this condition. Mesenchymal stem cells (MSCs) show the most potential for stem cell therapy of osteoarthritis. In fact, MSCs can differentiate into certain mesodermal tissues such as cartilage and bone. Therefore, in the present study, we applied adipose tissue-derived MSCs to osteoarthritis treatment. This study aimed to evaluate the clinical efficiency of autologous adipose tissue-derived MSC transplantation in patients with confirmed osteoarthritis at grade II and III. Adipose tissue was isolated from the belly, and used for extraction of the stromal vascular fraction (SVF). The SVF was mixed with activated platelet-rich plasma before injection. The clinical efficiencies were evaluated by the pain score (VAS), Lysholm score, and MRI findings. We performed the procedure in 21 cases from 2012 to 2013. All 21 patients showed improved joint function after 8.5 months. The pain score decreased from 7.6±0.5 before injection to 3.5±0.7 at 3 months and 1.5±0.5 at 6 months after injection. The Lysholm score increased from 61±11 before injection to 82±8.1 after injection. Significant improvements were noted in MRI findings, with increased thickness of the cartilage layer. Moreover, there were no side-effects or complications related to microorganism infection, graft rejection, or tumorigenesis. These results provide a new opportunity for osteoarthritis treatment. Level of evidence: IV.

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“…Many studies have used femoral hyaline chondrocytes or bone marrow stem cells as in vitro models to study the regulatory mechanisms of endochondral ossification. 3 However, the condylar chondrocytes are fibrochondrocytes, so there may be some difference in the regulatory mechanisms of endochondral ossification between the condylar and the hyaline chondrocytes. To the best of our knowledge, no papers have been published that have described the different properties between fibrochondrocytes and hyaline chondrocytes, so it is necessary to build in vitro models and study the different properties of fibrochondrocytes and hyaline chondrocytes.…”

Section: Introductionmentioning

confidence: 99%

Study of differential properties of fibrochondrocytes and hyaline chondrocytes in growing rabbits

Huang

et al. 2015

British Journal of Oral and Maxillofacial Surgery

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Scaffold-assisted cartilage tissue engineering using infant chondrocytes from human hip cartilage

Cited by 30 publications

References 59 publications

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

Symptomatic knee osteoarthritis treatment using autologous adipose derived stem cells and platelet-rich plasma: a clinical study

Study of differential properties of fibrochondrocytes and hyaline chondrocytes in growing rabbits

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