Scabies presenting with bullous pemphigoid-like lesions

Ansarin, H; Jalali, Mir Hadi Aziz; Mazloomi, Shadi; Soltani-Arabshahi, Razieh; Setarehshenas, Roya

doi:10.5070/d30614h8tw

Cited by 23 publications

(3 citation statements)

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“…The exact mechanism of bullous development in a scabetic patient is not well known, although many possible explanations were suggested. Either it is attributed to superadded secondary bacterial infection by Staphylococcus aureus or it may result from direct trauma or the release of lytic enzymes by the scabetic mites that may change the basement membrane zone with subsequent production of autoimmune antibodies with subsequent release of cytokines and other inflammatory mediators [10]. In addition, it is reported that mite proteins may cross-react with basement membrane antigens resulting in autoimmune antibodies that activate immunoreaction with subsequent cleft formation and production of bullae [10].…”

Section: Discussionmentioning

confidence: 99%

“…Either it is attributed to superadded secondary bacterial infection by Staphylococcus aureus or it may result from direct trauma or the release of lytic enzymes by the scabetic mites that may change the basement membrane zone with subsequent production of autoimmune antibodies with subsequent release of cytokines and other inflammatory mediators [10]. In addition, it is reported that mite proteins may cross-react with basement membrane antigens resulting in autoimmune antibodies that activate immunoreaction with subsequent cleft formation and production of bullae [10]. Bornhovd and others believed that the persistence of scabies might result in a specific immune response that activate T-helper 2 cells causing an increase in interleukin 5 and eosinophilia that led to bullous formation [10].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, it is reported that mite proteins may cross-react with basement membrane antigens resulting in autoimmune antibodies that activate immunoreaction with subsequent cleft formation and production of bullae [10]. Bornhovd and others believed that the persistence of scabies might result in a specific immune response that activate T-helper 2 cells causing an increase in interleukin 5 and eosinophilia that led to bullous formation [10].…”

Section: Discussionmentioning

confidence: 99%

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A case series on bullous pemphigoid like scabies: A diagnostic challenge

Hamdi¹,

Alhamdi²

2022

Indian J Case Reports

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Scabies is an ectoparasitic infection caused by Sarcoptes scabiei var. hominis in humans. Accurate figures of the prevalence of scabies are difficult to obtain, it seems to affect around 100–300 million people worldwide. Scabies is usually transmitted by close intimate physical contacts, such as the sharing of a bed or prolonged hand-holding. Scabies mites survive for 24–36 h outside of human bodies. Itching is the most obvious manifestation of scabies, which is usually sparing the face in adult classic scabies. The onset occurs 3–4 weeks after acquiring the infection. Bullous pemphigoid-like scabies is one of the atypical and rare forms of scabies that may be overlooked and mismanaged, where only 44 cases worldwide with this mode of presentation were reported. Here, we reported a series of three cases of bullous pemphigoid-like scabies, which presented with nocturnal itching and vesiculobullous lesions that are to the best of our knowledge the first cases reported in our country

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A case series on bullous pemphigoid like scabies: A diagnostic challenge

Hamdi¹,

Alhamdi²

2022

Indian J Case Reports

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Local Treatments and Supportive Care

Feld

Sami

2016

Autoimmune Bullous Diseases

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Scabies in the Nursing Home

Suwandhi

Dharmarajan

2014

Curr Infect Dis Rep

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Scabies infection is antediluvian and ubiquitous both in developing and developed countries, yet often neglected. Scabies has a predilection to infect vulnerable subsets of population in crowding conditions, typically applicable to residents in the nursing home. The mite incites a unique immunological response from human hosts. Scabies does not manifest as a singular skin condition and may present atypically in older adults, the majority of nursing home residents, where delay has deleterious consequences. Further, pruritus or itching, the hallmark of scabies infection, is a common complaint from a variety of causes among older adults. Hence, the diagnosis is often delayed or missed. There are several pharmacological treatment options; long-term care practitioners need to understand the characteristics of each agent before selection. Even more relevant is the importance of nonpharmacological aspects of management, crucial in the success of averting spread or outbreaks in long-term care settings.

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Scabies presenting with bullous pemphigoid-like lesions

Cited by 23 publications

References 0 publications

A case series on bullous pemphigoid like scabies: A diagnostic challenge

A case series on bullous pemphigoid like scabies: A diagnostic challenge

Local Treatments and Supportive Care

Scabies in the Nursing Home

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