scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase

Wang, Ying; Sun, Shuo; Zhai, Jingxu; Liu, Yuanyuan; Song, Chaoyuan; Sun, Cuimei; Li, Qiang; Liu, Jianqiang; Jiang, Hong; Liu, Yaling

doi:10.1007/s00221-023-06721-7

Exp Brain Res

2023

DOI: 10.1007/s00221-023-06721-7

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scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase

Ying Wang,

Shuo Sun,

Jingxu Zhai

et al.

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2024

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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Issa,

Fayoud,

Shaimardanova

et al. 2024

Biomedicines

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Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.

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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Issa,

Fayoud,

Shaimardanova

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase

Cited by 1 publication

References 45 publications

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

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