Say No to the Us Preventative Task Force Recommendation to No Longer Offer Prostate Cancer Screening After Age 75?

Moul, Judd W.; Sun, Leon; Lack, Benjamin D; Robertson, Cary N.; Polascik, Thomas J.; Donatucci, Craig F.; Maloney, Kelly E.; Price, Marva M.; Albala, David; Caire, Arthur

doi:10.1016/s0022-5347(09)62222-9

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Should Age Affect the Psa Threshold For Prostate Biopsy?1

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2010

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“…24 These guidelines have generated controversy in both the medical community and general public. For example, Moul et al 25 surveyed 340 men presenting for a free CaP screening and reported that 78% were “upset” by this recommendation. More significantly, these guidelines were issued in the absence of level 1 evidence on screening in men older than 75 years.…”

Section: Should Age Affect the Psa Threshold For Prostate Biopsy?mentioning

confidence: 99%

Prostate Cancer Screening and Determining the Appropriate Prostate-Specific Antigen Cutoff Values

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Loeb

2010

J Natl Compr Canc Netw

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Prostate-specific antigen (PSA) in combination with digital rectal examination forms the basis for current prostate cancer (CaP) screening programs. Although PSA screening was recently shown to reduce CaP-specific mortality in the European randomized trial, its limitations include the risk for unnecessary prostate biopsy and the diagnosis and treatment of some CaP that might never have caused suffering or death. A potential way to minimize these pitfalls is through the use of derivatives of PSA, particularly PSA kinetics, to increase the specificity for clinically relevant CaP. CaP is the second-leading cause of cancer death in men in the United States and many other westernized countries; accordingly, judicious screening of healthy men allows for diagnosis sufficiently early that all options (i.e., treatment or surveillance) are still available in most cases.

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Section: Should Age Affect the Psa Threshold For Prostate Biopsy?mentioning

confidence: 99%