Saxagliptin ameliorated the depressive-like behavior induced by chronic unpredictable mild stress in rats: Impact on incretins and AKT/PI3K pathway

Nazeem, MennatAllah; Wahdan, Sara A.; El-Naga, Reem N.; Gad, Amany M.

doi:10.1016/j.ejphar.2021.174602

Cited by 6 publications

(1 citation statement)

References 58 publications

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“…The PI3K/AKT signaling pathway is a key information molecule chain that promotes cell survival and maintains its normal function. It has been confirmed that the PI3K/AKT pathway is inhibited in depression animal model induced by chronic stress (Nazeem et al, 2021). The downregulation of the PI3K/AKT signaling pathway can lead to increased phosphorylation of NF-κB, providing negative feedback regulation to the TLR4/NF-κB signaling pathway (Zhou et al, 2022).…”

Section: Discussionmentioning

confidence: 85%

Polygonum sibiricum polysaccharides exert the antidepressant‐like effects in chronic unpredictable mild stress‐induced depressive mice by modulating microbiota‐gut‐brain axis

Zhang

Sun

Liu

et al. 2023

Phytotherapy Research

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Polygonum sibiricum polysaccharides (PSP) are one of the main active components of Polygonatum sibiricum, which is a traditional Chinese medicine with food and drug homologies. Recent studies have revealed the antidepressant-like effects of PSP. However, the precise mechanisms have not been clarified. Therefore, the present study was conducted to explore that whether PSP could exert the antidepressant-like effects via microbiota-gut-brain (MGB) axis in chronic unpredictable mild stress (CUMS)-induced depressive mice by transplantation of fecal microbiota (FMT) from PSP administration mice. FMT markedly reversed the depressive-like behaviors of CUMS-induced mice in the open field, the sucrose preference, the tail suspension, the forced swimming, and the novelty-suppressed feeding tests. FMT significantly increased the levels of 5-hydroxytryptamine and norepinephrine, decreased the levels of the pro-inflammatory cytokines in the hippocampus and reduced the levels of corticosterone, an adrenocorticotropic-hormone, in the serum of CUMS-induced mice. In addition, administration of PSP and FMT significantly increased the expressions of ZO-1 and occludin in the colon and decreased the levels of lipopolysaccharide and interferon-γ in the serum of CUMSinduced mice. Moreover, administration of PSP and FMT regulated the signaling pathways of PI3K/AKT/TLR4/NF-κB and ERK/CREB/BDNF. Taken together, these findings indicated that PSP exerted antidepressant-like effects via the MGB axis.

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Section: Discussionmentioning

confidence: 85%