Saw-tooth vertical saccades in progressive supranuclear palsy

Kim, Min-Ku; Lee, Dongje; Yang, Xu; Kim, Hyojung; Choi, Jeong‐Yoon; Kim, Ji‐Soo

doi:10.1007/s00415-023-11696-0

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…76,77 Some reports have presented a "zig-zag" or "saw tooth" pattern where hypometric vertical saccades had a horizontal component, alike round the houses. 78,79 This pattern could be the combination of square wave jerks and hypometric vertical saccades pointing towards increased disease as a major compensatory mechanism employing more horizontal saccades and impairment of inhibitory burst neurones. 80 Volitional and memory guided saccade function are less reported in PSP.…”

Section: Progressive Supranuclear Palsymentioning

confidence: 99%

Detecting Abnormal Eye Movements in Patients with Neurodegenerative Diseases – Current Insights

Sekar,

Panouillères,

Kaski

2024

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This review delineates the ocular motor disturbances across a spectrum of neurodegenerative disorders, including Alzheimer's Disease (AD) and related disorders (ADRD), Parkinson's Disease (PD), atypical parkinsonism, and others, leveraging advancements in eye-tracking technology for enhanced diagnostic precision. We delve into the different classes of eye movements, their clinical assessment, and specific abnormalities manifesting in these diseases, highlighting the nuanced differences and shared patterns. For instance, AD and ADRD are characterized by increased saccadic latencies and instability in fixation, while PD features saccadic hypometria and mild smooth pursuit impairments. Atypical parkinsonism, notably Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS), presents with distinct ocular motor signatures such as vertical supranuclear gaze palsy and saccadic apraxia, respectively. Our review underscores the diagnostic value of eye movement analysis in differentiating between these disorders and also posits the existence of underlying common pathological mechanisms. We discuss how eye movements have potential as biomarkers for neurodegenerative diseases but also some of the existing limitations.

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