“Saw-tooth” Pattern in the Flow-volume Loop

Vincken, WG; Costo, M.G.

doi:10.1378/chest.88.3.480-a

Cited by 10 publications

(5 citation statements)

References 1 publication

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“…In individual patients, SDB could be related to rigidity of muscles of the chest wall, restricted lung volumes secondary to changes in posture/kyphoscoliosis, or altered flow volume loop due to 4-8Hz oscillations in upper airway muscles[274,275]. Interestingly, there was no increase in sleep apnea in PD patients with camptocormia[276].…”

Section: Sleep Related Breathing Disordersmentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

266

249

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Sleep disorders are among the most common non-motor manifestations in Parkinson’s disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005-2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. We discuss the epidemiology, etiology, clinical implications, associated features, evaluation measures, and management of these disorders. The influence on sleep of medications used in the treatment of motor and non-motor symptoms of PD is detailed. Additionally, we suggest areas in need of further research.

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Section: Sleep Related Breathing Disordersmentioning

confidence: 99%

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

Chahine

Amara

Videnović

2017

Sleep Medicine Reviews

266

249

View full text Add to dashboard Cite

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“…Biologic plausibility exists for PD itself being involved in OSA pathogenesis. The upper airway musculature may be affected by involuntary movements resulting in abnormal spirometry consistent with upper airway obstruction [ 54 ], which improves with levodopa [ 55 ]. These disturbances may be exacerbated in sleep, resulting in OSA.…”

Section: Osa Prevalence In Pd and Possible Pathogenic Mechanismsmentioning

confidence: 99%

The Interaction between Obstructive Sleep Apnea and Parkinson’s Disease: Possible Mechanisms and Implications for Cognitive Function

Kamińska

Lafontaine

Kimoff

2015

Parkinson's Disease

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Parkinson's disease (PD) is a relentlessly progressive neurodegenerative disorder associated with hallmark motor and nonmotor symptoms (NMS) such as sleep disturbances and cognitive dysfunction. While dopaminergic treatments have improved the motor aspects of PD, progression remains inevitable. Research has recently increasingly focused on strategies to modify disease progression and on nonmotor manifestations of PD, given their impact on patients' quality of life. Obstructive sleep apnea (OSA) is a treatable sleep disorder, common in the general population, associated with excessive daytime sleepiness and neurocognitive deficits. Neuroimaging has demonstrated structural and functional changes in OSA patients; in animal models, OSA causes brain inflammation and oxidative injury, including in key areas involved in PD pathophysiology such as locus coeruleus. The prevalence of OSA in PD has been variable in studies to date, and potential consequences and interrelationship between the two disorders have not been well studied. There is however emerging evidence that OSA is associated with increased NMS in PD, particularly cognitive dysfunction. This review focuses on the possible interrelationship between OSA and PD. Mechanisms promoting OSA in PD will be reviewed, as well as mechanisms whereby OSA can affect the neurodegenerative process in PD.

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“…Larger randomized studies are needed to confirm these results and assess feasibility and safety of MAD in this population. Upper airway obstruction can also respond to levodopa [139][140][141][142][143]. Supporting this hypothesis, our group found that night-time treatment with long acting levodopa was associated with reduced OSA severity in PD patients, suggesting it could be a potential alternative to PAP therapy [144].…”

Section: Treatment Of Osa In Neurodegenerative Diseases: Benefits Andmentioning

confidence: 60%

“…The other subtype exhibits a more obstructive pattern on spirometry due to upper airway muscle instability [138]. Upper airway obstruction during wakefulness can respond to levodopa [139][140][141][142][143]. PD-related upper airway dysfunction can contribute to a sleep-associated decrease in upper airway dilator activity and stability, further predisposing to OSA.…”

Section: Osa Pathogenesis In Pdmentioning

confidence: 99%

Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment

Lajoie

Lafontaine

Kimoff

et al. 2020

JCM

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Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent upper airway obstruction during sleep resulting in intermittent hypoxemia and sleep fragmentation. Research has recently increasingly focused on the impact of OSA on the brain’s structure and function, in particular as this relates to neurodegenerative diseases. This article reviews the links between OSA and neurodegenerative disease, focusing on Parkinson’s disease, including proposed pathogenic mechanisms and current knowledge on the effects of treatment.

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“Saw-tooth” Pattern in the Flow-volume Loop

Cited by 10 publications

References 1 publication

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015

The Interaction between Obstructive Sleep Apnea and Parkinson’s Disease: Possible Mechanisms and Implications for Cognitive Function

Obstructive Sleep Apnea in Neurodegenerative Disorders: Current Evidence in Support of Benefit from Sleep Apnea Treatment

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